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Opioid Receptors and Heart Resistance to Arrhythmogenic Factors

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Abstract

We present detailed data on the role of central and peripheral opioid receptors in the regulation of heart resistance to arrhythmogenic factors. Stimulation of peripheral δ2- and κ1-receptors increases heart resistance to the arrhythmogenic effect of acute ischemia and reperfusion. Activation of peripheral μ- and δ1-opioid receptors improves electrical stability of the heart in animals with postinfarction cardiosclerosis. Possible mechanisms for opioidergic regulation of heart resistance to arrhythmogenic factors are discussed.

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Authors and Affiliations

  1. Institute of Cardiology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences, Tomsk State Training University, Russia

    Yu. B. Lishmanov & L. N. Maslov

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  1. Yu. B. Lishmanov
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  2. L. N. Maslov
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Lishmanov, Y.B., Maslov, L.N. Opioid Receptors and Heart Resistance to Arrhythmogenic Factors. Bulletin of Experimental Biology and Medicine 138, 107–112 (2004). https://doi.org/10.1023/B:BEBM.0000048363.84047.10

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