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Antigenic Differences between apo-B in Native and Circulating Modified Low-Density Lipoproteins

  • I. V. Suprun
  • A. A. Melnichenko
  • E. V. Yanushevskaya
  • T. N. Vlasik
  • I. A. Sobenin
  • O. M. Panasenko
  • A. N. Orekhov
Article
  • 23 Downloads

Abstract

The state of apo-B in native and circulating modified low-density lipoproteins was studied by solid-phase enzyme immunoassay. We studied the interaction of these particles with monoclonal antibodies to apo-B of low-density lipoproteins. Native and circulating modified low-density lipoproteins had different affinity for the studied antigens. Our results illustrate conformational changes in apo-B of circulating modified low-density lipoproteins compared to native low-density lipoproteins. These changes probably contribute to increased accumulation of particles in vascular cells and their transformation into foam cells giving way to atherosclerotic vascular lesions.

low-density lipoproteins modified low-density lipoproteins apo-B atherosclerosis 

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REFERENCES

  1. 1.
    V. V. Tertov, V. V. Kaplun, I. A. Sobenin, et al., Byull. Eksp. Biol. Med., 122, No. 7, 37–39 (1996).Google Scholar
  2. 2.
    E. V. Yanushevskaya, N. V. Valentinova, N. V. Medvedeva, et al., Angiol. Sosud. Khir., 5, Appl., 241–251.Google Scholar
  3. 3.
    A. N. Orekhov, V. V. Tertov, D. N. Mukhin, et al., Biochem. Biophys. Res. Commun., 162, 206–211 (1989).PubMedGoogle Scholar
  4. 4.
    A. N. Orekhov, V. V. Tertov, I. A. Sobenin, et al., J. Lipid Res., 33, 805–807 (1992).PubMedGoogle Scholar
  5. 5.
    V. V. Tertov, G. Bittolo-Bon, I. A. Sobenin, et al., Exp. Mol. Biol., 62, 166–172 (1995).Google Scholar
  6. 6.
    V. V. Tertov and A. N. Orekhov, Exp. Mol. Pathol., 64, 127 (1997).PubMedGoogle Scholar
  7. 7.
    V. V. Tertov, A. N. Orekhov, I. A. Sobenin, et al., J. Lipid Res., 34, 365–375 (1993).PubMedGoogle Scholar
  8. 8.
    V. V. Tertov, I. A. Sobenin, Z. A. Gabbazov, et al., Lab. Invest., 67, 665–675 (1992).PubMedGoogle Scholar
  9. 9.
    V. V. Tertov, I. A. Sobenin, A. G. Tonevitsky, et al., Biochem. Biophys. Res. Commun., 167, 1122–1127 (1990).PubMedGoogle Scholar

Copyright information

© Plenum Publishing Corporation 2004

Authors and Affiliations

  • I. V. Suprun
    • 1
  • A. A. Melnichenko
    • 1
  • E. V. Yanushevskaya
    • 1
  • T. N. Vlasik
    • 1
  • I. A. Sobenin
    • 1
  • O. M. Panasenko
    • 1
  • A. N. Orekhov
    • 1
  1. 1.Laboratory for Mechanisms of Atherogenesis, Institute of Experimental Cardiology, Russian Research-and-Production Complex for Cardiology, Russian Ministry of Health; Institute of AtherosclerosisRussian Academy of Natural SciencesMoscow

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