Abstract
Low protein content in the ration of rat pups during transfer from mixed to definitive nutrition (days 21-30 of life) has a negative impact on digestive function of the small intestine and trophic and barrier functions of the large intestine, liver, and kidneys and increases (sucrase, glycyl-L-leucin dipeptidase) or decreases (alkaline phosphatase, aminopeptidase M, glycyl-L-leucine dipeptidase) enzyme activities in these organs in 6-month-old rats. Protein deficiency during the early ontogeny modulates functioning of the enzyme systems in digestive and non-digestive organs in adult life, which can lead to the development of not only gastrointestinal, but other visceral diseases.
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Timofeeva, N.M., Nikitina, A.A., Egorova, V.V. et al. Relationship between Protein Deficiency in the Ration of Rats during Early Ontogeny and Function of Enzyme Systems of Digestive and Non-Digestive Organs in Adult Life. Bulletin of Experimental Biology and Medicine 138, 8–11 (2004). https://doi.org/10.1023/B:BEBM.0000046924.75052.f3
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DOI: https://doi.org/10.1023/B:BEBM.0000046924.75052.f3