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Effect of Testosterone Derivatives Administered to Pregnant Rats on the Brain of Their Offspring (Delayed Consequences)

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Abstract

We examined the offspring of rats receiving sustanon with testosterone derivatives on day 19 of pregnancy. At the age of 1 month, these rats differed from control animals in the indexes of higher nervous activity. The relative weight of the brain increased in 54-day-old rats receiving the hormone. Female rats were characterized by increased sudanophilia of the white matter in cerebellar hemispheres and high RNA content in layer V neurons of the parietal lobe, increased volume of nuclei in hippocampal neurons, weight of the ovaries (tendency), size of the largest follicles, and high activity of 3β-ol-steroid dehydrogenase. The weight of the adrenal glands and 3β-ol-steroid dehydrogenase activity in adrenocortical cells of the fascicular zone increased in male rats.

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Authors and Affiliations

  1. Department of Histology, Far-Eastern State Medical University, Khabarovsk

    B. Ya. Ryzhavskii, E. V. Vasileva, I. R. Eremenko, Yu. A. Sapozhnikov, T. V. Sokolova & Yu. Yu. Rudman

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  1. B. Ya. Ryzhavskii
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  2. E. V. Vasileva
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  3. I. R. Eremenko
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  4. Yu. A. Sapozhnikov
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  5. T. V. Sokolova
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  6. Yu. Yu. Rudman
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Ryzhavskii, B.Y., Vasileva, E.V., Eremenko, I.R. et al. Effect of Testosterone Derivatives Administered to Pregnant Rats on the Brain of Their Offspring (Delayed Consequences). Bulletin of Experimental Biology and Medicine 137, 628–631 (2004). https://doi.org/10.1023/B:BEBM.0000042730.60631.3d

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  • DOI: https://doi.org/10.1023/B:BEBM.0000042730.60631.3d

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