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Effect of Endothelin-1 on Apoptosis, Proliferation, and Protein Synthesis in Cardiomyocytes of Newborn Albino Rats

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Abstract

Five intraperitoneal injections of endothelin-1 (100 μg/kg) to newborn albino rats on days 2-6 of life did not change the number of nuclei expressing PCNA in the left-ventricular myocardium. The number of nucleoli, area and perimeter of cardiomyocytes (isolated by the method of alkaline dissociation) increased. The number of myocyte nuclei in the state of apoptosis (evaluated by the TUNEL method) increased significantly. Presumably, partial loss of cardiomyocytes as a result of apoptosis activation after treatment with endothelin-1 is compensated by increased size and transcription activity of remaining cardiomyocytes.

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Authors and Affiliations

  1. Central Research Laboratory, Far-Eastern State Medical University, Khabarovsk

    N. P. Melnikova, S. S. Timoshin, L. J. Pelliniemi, E. Jokinen & E. Abdelwahid

  2. Laboratory of Electron Microscopy, University of Turku, Russia

    N. P. Melnikova, S. S. Timoshin, L. J. Pelliniemi, E. Jokinen & E. Abdelwahid

  3. Department of Pediatrics, University of Helsinki, Russia

    N. P. Melnikova, S. S. Timoshin, L. J. Pelliniemi, E. Jokinen & E. Abdelwahid

  4. Department of Pediatrics and Medical Research Laboratories, University of Turku, Finland

    N. P. Melnikova, S. S. Timoshin, L. J. Pelliniemi, E. Jokinen & E. Abdelwahid

Authors
  1. N. P. Melnikova
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  2. S. S. Timoshin
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  3. L. J. Pelliniemi
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  4. E. Jokinen
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  5. E. Abdelwahid
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Melnikova, N.P., Timoshin, S.S., Pelliniemi, L.J. et al. Effect of Endothelin-1 on Apoptosis, Proliferation, and Protein Synthesis in Cardiomyocytes of Newborn Albino Rats. Bulletin of Experimental Biology and Medicine 137, 606–608 (2004). https://doi.org/10.1023/B:BEBM.0000042724.11867.fa

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  • DOI: https://doi.org/10.1023/B:BEBM.0000042724.11867.fa

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