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Relationship between High Sensitivity of Suckling Mice to Hepatocarcinogenic and Antiglucocorticoid Effects of o-Aminoazotoluene and Diethylnitrosamine

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Abstract

Suckling mice were more sensitive to the hepatocarcinogenic effect of various carcinogens compared to adult animals. After treatment with o-aminoazotoluene and diethylnitrosamine HNF3-DNA-binding capacity and glucocorticoid-induced liver tyrosine aminotransferase activity in suckling mice decreased more significantly than in adult animals.

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Authors and Affiliations

  1. Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk

    S. I. Il'nitskaya, E. D. Vasileva, K. Yu. Kropachev & V. I. Kaledin

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  1. S. I. Il'nitskaya
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  2. E. D. Vasileva
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  3. K. Yu. Kropachev
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  4. V. I. Kaledin
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Il'nitskaya, S.I., Vasileva, E.D., Kropachev, K.Y. et al. Relationship between High Sensitivity of Suckling Mice to Hepatocarcinogenic and Antiglucocorticoid Effects of o-Aminoazotoluene and Diethylnitrosamine. Bulletin of Experimental Biology and Medicine 137, 548–550 (2004). https://doi.org/10.1023/B:BEBM.0000042708.97983.23

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  • DOI: https://doi.org/10.1023/B:BEBM.0000042708.97983.23

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