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Immunoprotective Effects of Prolactin during Stress-Induced Immune Dysfunction

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Abstract

We showed for the first time that prolactin stimulates the synthesis and release of immunomodulating cytokines and lymphocyte-activating factors (e.g., interleukin-1) by peritoneal macrophages. Prolactin abolished the stress-induced inhibition of proliferation of peripheral blood lymphocytes and increased cell sensitivity to regulatory effects of interleukin-1 in the reaction of lymphocyte blast transformation. These data illustrate the mechanism of immunoprotective activity of prolactin during stress.

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Authors and Affiliations

  1. Department of General Pathology and Pathophysiology, Institute of Experimental Medicine, Russian Academy of Medical Sciences, St. Petersburg

    E. E. Fomicheva, E. A. Nemirovich-Danchenko & E. A. Korneva

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  1. E. E. Fomicheva
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  2. E. A. Nemirovich-Danchenko
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  3. E. A. Korneva
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Fomicheva, E.E., Nemirovich-Danchenko, E.A. & Korneva, E.A. Immunoprotective Effects of Prolactin during Stress-Induced Immune Dysfunction. Bulletin of Experimental Biology and Medicine 137, 544–547 (2004). https://doi.org/10.1023/B:BEBM.0000042707.46061.5d

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  • DOI: https://doi.org/10.1023/B:BEBM.0000042707.46061.5d

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