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Dose-Dependent Effects and Specificity of Action of Antibodies to Endogenous Regulators in Ultralow Doses

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Abstract

We studied the effects of antibodies against interferon-γ, erythropoietin, and tumor necrosis factor-α in ultralow doses on the production of endogenous interferon-γ. Course peroral treatment with potentiated antibodies to interferon-γ in various dilutions produced similar changes in experimental animals. The treatment stimulated spontaneous production of endogenous interferon-γ by mouse lymphocytes. It should be emphasized that antibodies to other cytokines in ultralow doses did not stimulate interferon-γ production. These data illustrate the specificity of action of antibodies to endogenous regulators in ultralow doses.

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REFERENCES

  1. I. P. Ashmarin and I. S. Freidlin, Zh. Evolyuts. Biokhim. Fiziol., 25, No. 2, 176–182 (1989).

    Google Scholar 

  2. E. B. Burlakova, A. A. Konradov, and I. B. Khudyakov, Izv. Akad. Nauk SSSR, No. 2, 184–194 (1990).

  3. E. D. Gol'dberg, A. M. Dygai, and V. P. Shakhov, Tissue Culture Methods in Hematology [in Russian], Tomsk (1992).

  4. V. G. Zilov, K. V. Sudakov, and O. I. Epstein, Elements of Informational Biology and Medicine [in Russian], Moscow (2000).

  5. N. P. Kravkov, Usp. Eksper. Biol., Nos. 3-4, 147–172 (1924).

  6. A. B. Poletaev, S. G. Morozov, and I. E. Kovalev, Regulatory Metasystem (Immunoneuroendocrine Regulation of Homeostasis) [in Russian], Moscow (2002).

  7. E. Yu. Sherstoboev, N. V. Masnaya, A. A. Churin, et al., Byull. Eksp. Biol. Med., Suppl. 4, 79–82 (2002).

  8. O. I. Epstein, N. A. Beregovoi, T. M. Pankova, et al., Ibid., Suppl. 1, 20–23 (2003).

  9. E. Davenas, F. Beauvais, J. Amara, et al., Nature, 333, No. 6176, 816–818 (1988).

    Google Scholar 

  10. G. Harisch and J. Dittmann, Biomedical Therapy, 15, No. 2, 40–46 (1997).

    Google Scholar 

  11. S. Raga, M. R. Julia, C. Crespi, et al., Respir. Res., 4, No. 1, 9 (2003).

  12. D. R. Wesemann and E. N. Benveniste, J. Immunol., 171, No. 10, 5313–5319 (2003).

    Google Scholar 

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Authors and Affiliations

  1. Institute of Pharmacology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences, Tomsk

    O. I. Epstein, E. Yu. Sherstoboev, A. V. Martyushev-Poklad, Yu. L. Dugina, S. A. Sergeeva & A. M. Dygai

  2. Research-and-Production Company “Materia Medica Holding”, Moscow

    O. I. Epstein, E. Yu. Sherstoboev, A. V. Martyushev-Poklad, Yu. L. Dugina, S. A. Sergeeva & A. M. Dygai

Authors
  1. O. I. Epstein
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  2. E. Yu. Sherstoboev
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  3. A. V. Martyushev-Poklad
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  4. Yu. L. Dugina
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  5. S. A. Sergeeva
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  6. A. M. Dygai
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Epstein, O.I., Sherstoboev, E.Y., Martyushev-Poklad, A.V. et al. Dose-Dependent Effects and Specificity of Action of Antibodies to Endogenous Regulators in Ultralow Doses. Bulletin of Experimental Biology and Medicine 137, 460–462 (2004). https://doi.org/10.1023/B:BEBM.0000038153.60142.84

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  • DOI: https://doi.org/10.1023/B:BEBM.0000038153.60142.84

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