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Fibrinogen and Its Oxidized Form Induce Interleukin-2 Production in Cultured Endothelial Cells of Human Vessels

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Abstract

Oxidized fibrinogen was more potent than native fibrinogen in inducing interleukin-8 production in primary culture of human endothelial cells. The optimal concentration of oxidized fibrinogen was 3 mg/ml. The optimal time of UV irradiation was 17 min. Secretion of interleukin-8 was maximum during culturing of endothelial cells in a serum-free medium.

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Authors and Affiliations

  1. Laboratory for Biophysical Bases of Pathology, Institute of Physicochemical Medicine, Russian Ministry of Health, Moscow

    O. A. Azizova, E. V. Maksyanina, Yu. A. Romanov, A. V. Aseichev & O. N. Scheglovitova

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  1. O. A. Azizova
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  2. E. V. Maksyanina
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  3. Yu. A. Romanov
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  4. A. V. Aseichev
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  5. O. N. Scheglovitova
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Azizova, O.A., Maksyanina, E.V., Romanov, Y.A. et al. Fibrinogen and Its Oxidized Form Induce Interleukin-2 Production in Cultured Endothelial Cells of Human Vessels. Bulletin of Experimental Biology and Medicine 137, 358–360 (2004). https://doi.org/10.1023/B:BEBM.0000035129.62456.29

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  • DOI: https://doi.org/10.1023/B:BEBM.0000035129.62456.29

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