Abstract
Rhythmic stimulation of nerve-muscle preparation of frog sternal muscle bathed in low-Ca2+ saline increased the release of neurotransmitter (facilitation) and modified the shape of extracellular response of nerve terminal (decreased phase III amplitude). Iberiotoxin and 4-aminopyridine modified the dynamics these processes. We conclude that inactivation of potential-dependent K+-channels and activation of calcium-dependent K+-channels in frog motor nerve terminals during rhythmic activity modulate Ca2+ influx into nerve terminals and contribute into facilitation of neurotransmitter secretion. The degree of these mechanisms depends on the rate of synaptic rhythmic activity.
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Mukhamedyarov, M.A., Minlebaev, M.G. & Zefirov, A.L. Effect of Blockers of Potential-Dependent and Calcium-Activated K+-Channels on Facilitation of Neuromuscular Transmission. Bulletin of Experimental Biology and Medicine 137, 323–326 (2004). https://doi.org/10.1023/B:BEBM.0000035119.89379.23
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DOI: https://doi.org/10.1023/B:BEBM.0000035119.89379.23