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Mechanisms Underlying Diquertin-Mediated Regulation of Neutrophil Function in Patients with Non-Insulin-Dependent Diabetes Mellitus

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Abstract

We studied the effects of dihydroquercetin (3.3.4.5.7-pentahydroxyflavanone, a new Russian patented preparation) on functional activity of polymorphonuclear neutrophils from patients with non-insulin-dependent diabetes mellitus. Flavonoids (quercetin and its derivative dihydroquercetin) dose-dependently suppressed generation of anion radicals and hypochlorous acid and production of malonic dialdehyde during oxidation of neutrophil membranes. Dihydroquercetin decreased activities of protein kinase C and myeloperoxidase in activated polymorphonuclear neutrophils and could bind transition metals (Fe2+). These properties determine the ability of dihydroquercetin to decrease in vitro functional activity of polymorphonuclear neutrophils from patients with non-insulin-dependent diabetes mellitus.

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Authors and Affiliations

  1. Department of General Pathology and Pathophysiology, Russian Medical Academy of Postgraduate Education, Russian Ministry of Health, Moscow

    N. F. Fedosova, S. V. Alisievich, K. V. Lyadov, E. P. Romanova, I. A. Rud'ko & A. A. Kubatiev

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  1. N. F. Fedosova
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  2. S. V. Alisievich
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  3. K. V. Lyadov
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  4. E. P. Romanova
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  5. I. A. Rud'ko
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  6. A. A. Kubatiev
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Fedosova, N.F., Alisievich, S.V., Lyadov, K.V. et al. Mechanisms Underlying Diquertin-Mediated Regulation of Neutrophil Function in Patients with Non-Insulin-Dependent Diabetes Mellitus. Bulletin of Experimental Biology and Medicine 137, 143–146 (2004). https://doi.org/10.1023/B:BEBM.0000028124.90768.50

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  • DOI: https://doi.org/10.1023/B:BEBM.0000028124.90768.50

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