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Ethological Analysis of the Effects of Fluoglyzine on Mice Exposed to Chronic Social Stress

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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Ethological study of a new agent fluoglyzine (fluoxetine analog) was carried out. Porsolt test revealed a positive antidepressant effect of fluoglyzine in mice with pronounced depression-like state. This effect was more pronounced than the effect of fluoxetine. Both drugs effectively improved communicative activity of experimental animals. Anxiety tests showed no anxiolytic effects of fluoglyzine and fluoxetine.

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Authors and Affiliations

  1. Sector of Social Behavior Neurogenetics, Institute of Cytology and Genetics, Siberian Division of Russian Academy of Sciences, Novosibirsk

    D. F. Avgustinovich, I. L. Kovalenko, I. V. Sorokina, T. G. Tolstikova & A. G. Tolstikov

  2. Laboratory of Pharmacological Studies, Institute of Organic Chemistry, Siberian Division of Russian Academy of Sciences, Novosibirsk

    D. F. Avgustinovich, I. L. Kovalenko, I. V. Sorokina, T. G. Tolstikova & A. G. Tolstikov

  3. Institute of Technological Chemistry, Ural Division of Russian Academy of Sciences, Perm

    D. F. Avgustinovich, I. L. Kovalenko, I. V. Sorokina, T. G. Tolstikova & A. G. Tolstikov

Authors
  1. D. F. Avgustinovich
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  2. I. L. Kovalenko
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  3. I. V. Sorokina
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  4. T. G. Tolstikova
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  5. A. G. Tolstikov
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Avgustinovich, D.F., Kovalenko, I.L., Sorokina, I.V. et al. Ethological Analysis of the Effects of Fluoglyzine on Mice Exposed to Chronic Social Stress. Bulletin of Experimental Biology and Medicine 137, 86–89 (2004). https://doi.org/10.1023/B:BEBM.0000024395.16590.81

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  • DOI: https://doi.org/10.1023/B:BEBM.0000024395.16590.81

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