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Expression of Type IV Collagen by Lewis Pulmonary Carcinoma Cells

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Abstract

Study of the expression of type IV collagen by Lewis pulmonary carcinoma cells (PLMG-T, PLMG-M1, PLMG-M2) showed that these cells produce type IV collagen. The expression of type IV collagen in PLMG-T and PLMG-M2 cells approximately 2-fold surpassed that in PLMG-M1 cells. The number of active cells (synthesizing type IV collagen) in PLMG-M1 culture was 1.6 and 2.2 times lower than in PLMG-M2 and PLMG-T cultures, respectively. It was found that cell culture medium modulated expression of type IV collagen and this effect was mediated via cell receptors.

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Authors and Affiliations

  1. M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow

    G.P. Gaenko, S. V. Khaidukov & Yu. G. Molotkovskii

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  1. G.P. Gaenko
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  2. S. V. Khaidukov
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  3. Yu. G. Molotkovskii
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Gaenko, G., Khaidukov, S.V. & Molotkovskii, Y.G. Expression of Type IV Collagen by Lewis Pulmonary Carcinoma Cells. Bulletin of Experimental Biology and Medicine 137, 67–69 (2004). https://doi.org/10.1023/B:BEBM.0000024390.08829.ee

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  • DOI: https://doi.org/10.1023/B:BEBM.0000024390.08829.ee

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