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Modulatory Effect of 8-OH-DPAT on Behavior of Ovariectomized Female Rats

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Abstract

Behavior of ovariectomized rats was studied after chronic administration of serotonin 1A receptor agonist 8-OH-DPAT alone or in combination with 17β-estradiol for 14 days. The effect of 8-OH-DPAT on learning was evaluated in the conditioned passive avoidance task. Behavioral activity in elevated plus-maze and open field was recorded. Administration of 8-OH-DPAT to ovariectomized female rats increased the number of entries into open arms of the maze and the time spent there. Combination treatment of ovariectomized animals with 8-OH-DPAT and 17β-estradiol decreased total locomotor and emotional activity in the open field. Administration of 8-OH-DPAT alone or in combination with 17β-estradiol improved performance of the conditioned passive avoidance response.

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Authors and Affiliations

  1. S. V. Anichkov Department of Neuropharmacology, Institute of Experimental Medicine, Russian Academy of Medical Sciences, St. Petersburg

    N. S. Sapronov, Yu. O. Fedotova & E. I. Malygina

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  1. N. S. Sapronov
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  2. Yu. O. Fedotova
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  3. E. I. Malygina
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Sapronov, N.S., Fedotova, Y.O. & Malygina, E.I. Modulatory Effect of 8-OH-DPAT on Behavior of Ovariectomized Female Rats. Bulletin of Experimental Biology and Medicine 137, 43–46 (2004). https://doi.org/10.1023/B:BEBM.0000024383.75037.d1

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  • DOI: https://doi.org/10.1023/B:BEBM.0000024383.75037.d1

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