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Oxygen-Dependent Mechanisms Underlying the Antiischemic Effect of Verapamil and Amlodipine

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Abstract

Verapamil and amlodipine produced a potent antiischemic effect and reduced the area of myocardial infarction in rats. The observed changes were accompanied by inhibition of lipid peroxidation. In contrast to verapamil, amlodipine in a dose of 50 ng/ml in vitro decreased hemoglobin affinity for oxygen. Moreover, amlodipine in a concentration of 2 ng/ml decreased the content of malonic dialdehyde and activity of superoxide dismutase in the blood.

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Authors and Affiliations

  1. Russian State Medical University, Moscow

    S. V. Gatsura

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  1. S. V. Gatsura
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Gatsura, S.V. Oxygen-Dependent Mechanisms Underlying the Antiischemic Effect of Verapamil and Amlodipine. Bulletin of Experimental Biology and Medicine 137, 40–42 (2004). https://doi.org/10.1023/B:BEBM.0000024382.81356.04

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  • DOI: https://doi.org/10.1023/B:BEBM.0000024382.81356.04

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