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Effects of T-Activin and Vitamin E on Toxicity and Antitumor Activity of Cyclophosphamide

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Abstract

We studied the effect of combination treatment with T-activin and vitamin E on acute toxicity and antitumor activity of cyclophosphamide in mice. Combined administration of these preparations 1.37-fold increased the maximum permissible dose of cyclophosphamide without affecting its LD50 and delayed mouse death from cyclophosphamide toxicity. Most mice died only 3 days after combination treatment with the test preparations and cyclophosphamide in doses of LD16-LD84. The second peak of death from hematologic toxicity of cyclophosphamide was absent under these conditions. T-activin and vitamin E did not abolish the antitumor effect of cyclophosphamide on mice with subcutaneously implanted P-388 lympholeukemia. Tumor growth was suppressed by 100%.

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Authors and Affiliations

  1. Department of Pharmacology No. 1, Course of Clinical Pharmacology, Bashkirian State Medical University, Ufa; G. F. Gauze Institute of Search for New Antibiotics, Russian Academy of Medical Sciences, Moscow

    N. A. Mufazalova, I. D. Treshchalin, E. M. Treshchalina, L. A. Sedakova & N. V. Andronova

  2. N. N. Blokhin Russian Oncological Research Center, Russian Academy of Medical Sciences, Moscow

    N. A. Mufazalova, I. D. Treshchalin, E. M. Treshchalina, L. A. Sedakova & N. V. Andronova

Authors
  1. N. A. Mufazalova
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  2. I. D. Treshchalin
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  3. E. M. Treshchalina
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  4. L. A. Sedakova
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  5. N. V. Andronova
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Mufazalova, N.A., Treshchalin, I.D., Treshchalina, E.M. et al. Effects of T-Activin and Vitamin E on Toxicity and Antitumor Activity of Cyclophosphamide. Bulletin of Experimental Biology and Medicine 137, 37–39 (2004). https://doi.org/10.1023/B:BEBM.0000024381.69886.45

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  • DOI: https://doi.org/10.1023/B:BEBM.0000024381.69886.45

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