Abstract
Experiments on isolated perfused rat heart showed that nonselective μ- and δ-opiate receptor agonist dalargin decreased contractility of the intact heart, but had no effect on pump function of the ischemic myocardium. Dalargin analogue des-Tyr-dalargin not binding to opiate receptors decreased contractility of intact myocardium and isolated heart exposed to 45-min total ischemia. We hypothesize that the influence of dalargin is related to activation of cardiac δ-opiate receptors, while the inotropic effect of des-Tyr-dalargin is mediated by other receptors.
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Lasukova, T.V., Maslov, L.N., Podoksenov, Y.K. et al. Effect of Opiate Peptide Dalargin and Des-Tyr-Dalargin on Cardiac Pump Function during Ischemia-Reperfusion. Bulletin of Experimental Biology and Medicine 137, 27–30 (2004). https://doi.org/10.1023/B:BEBM.0000024378.48252.fb
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DOI: https://doi.org/10.1023/B:BEBM.0000024378.48252.fb