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Incorporation of Isoniazid into Liposomes with Different Lipid Composition

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Abstract

Liposomes containing isoniazid were obtained by extrusion of multilamellar phospholipid vesicles containing isoniazid, by ultrasound treatment, and from proliposomes. Optimal conditions for isolation of stable liposomes (200 nm in diameter) and the amount of incorporated isoniazid were determined by varying concentrations of phospholipids and isoniazid and by changing phospholipid composition.

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Authors and Affiliations

  1. M. V. Lomonosov Moscow State Academy of Fine Chemical Technology; Biological Faculty, M. V. Lomonosov Moscow State University, Russia

    G. M. Sorokoumova, A. A. Selishcheva, N. M. Malikova, A. S. Minina & V. I. Shvets

Authors
  1. G. M. Sorokoumova
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  2. A. A. Selishcheva
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  3. N. M. Malikova
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  4. A. S. Minina
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  5. V. I. Shvets
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Sorokoumova, G.M., Selishcheva, A.A., Malikova, N.M. et al. Incorporation of Isoniazid into Liposomes with Different Lipid Composition. Bulletin of Experimental Biology and Medicine 137, 17–19 (2004). https://doi.org/10.1023/B:BEBM.0000024375.65972.dd

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  • DOI: https://doi.org/10.1023/B:BEBM.0000024375.65972.dd

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