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Effect of Single Injection of Pentylenetetrazole in a Subconvulsive Dose on Cl- Conductance of the GABAA-Receptor Complex

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Abstract

Muscimol-stimulated Cl- conductance in brain cortex synaptoneurosomes from Wistar rats decreased 15 min after single intraperitoneal injection of pentylenetetrazole in a subconvulsive dose. These changes reflected a decrease in functional activity of the GABAA-receptor/Cl- ionophore complex. Muscimol-stimulated Cl- conductance in synaptoneurosomes returned to normal 48 h after pentylenetetrazole administration.

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Authors and Affiliations

  1. Laboratory of Functional Neurochemistry, Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow

    I. G. Rebrov, M. N. Karpova, A. A. Andreev, O. S. Kuzina, M. S. Kalinina, I. Yu. Abrosimov & N. P. Belykh

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  1. I. G. Rebrov
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  2. M. N. Karpova
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  3. A. A. Andreev
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  4. O. S. Kuzina
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  5. M. S. Kalinina
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  6. I. Yu. Abrosimov
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  7. N. P. Belykh
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Rebrov, I.G., Karpova, M.N., Andreev, A.A. et al. Effect of Single Injection of Pentylenetetrazole in a Subconvulsive Dose on Cl- Conductance of the GABAA-Receptor Complex. Bulletin of Experimental Biology and Medicine 137, 13–16 (2004). https://doi.org/10.1023/B:BEBM.0000024374.01961.23

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  • DOI: https://doi.org/10.1023/B:BEBM.0000024374.01961.23

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