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Bulletin of Experimental Biology and Medicine

, Volume 136, Issue 6, pp 569–571 | Cite as

Effect of Ivermectin on Function of Liver Macrophages

  • A. V. Viktorov
  • V. A. Yurkiv
Article

Abstract

Ivermectin had no effect on phagocytic function of liver macrophages, but blocked LPS-induced secretion of tumor necrosis factor, NO, prostaglandin E2, and increase of intracellular concentration of Ca2+. These inhibitory effects were observed only in the presence of chlorine ions in the extracellular medium, which attested to involvement of glycine-dependent chlorine channels.

ivermectin liver macrophages lipopolysaccharide phagocytosis 

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Copyright information

© Plenum Publishing Corporation 2003

Authors and Affiliations

  1. 1.Central Institute of EpidemiologyMinistry of Health of Russian FederationMoscow

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