Skip to main content

Flavonoids and Resveratrol as Regulators of Ah-Receptor Activity: Protection from Dioxin Toxicity

Bulletin of Experimental Biology and Medicine volume 136, pages 533–539 (2003)Cite this article

Circuit is open

Abstract

In 2002 FAO and WHO published a joint appeal to state and public organizations and scientific community to take every effort to control the contents of dioxin and related biphenyls in the environment and food products. The toxic effects of dioxin are realized via its interaction with the Ah-receptor. Here we reviewed modern notions about the structure and functions of Ah-receptor. Particular attention was given to antagonists and agonists of the Ah-receptor, including various flavonoids and resveratrol.

This is a preview of subscription content, access via your institution.

Access options

Buy single article

Instant access to the full article PDF.

39,95 €

Price includes VAT (Finland)

REFERENCES

  1. B. Glik and G. Pasternak, Molecular Biotechnology. Principles and Application [in Russian], Moscow (2002), p. 318.

  2. M. N. Zaprometov, Phenol Compounds: Distribution, Metabolism, and Functions in Plants [in Russian], Moscow (1993).

  3. L. I. Patrushev, Gene Expression [in Russian], Moscow (2000), p. 158.

  4. V. A. Tutel'yan, Vestn. SPb. Gos. Med. Akad., No. 1, 5-9 (2001).

  5. S. W. Allen, L. Mueller, S. N. Williams, et al., Drug Metabol. Dispos., 29, No. 8, 1074-1079 (2001).

    Google Scholar 

  6. Y. Amakura, T. Tsutsumi, M. Nakamura, et al., Biol. Pharm. Bull., 26, No. 4, 532-539 (2003).

    Google Scholar 

  7. P. Andersson, J. McGuire, C. Rubio, et al., Proc. Natl. Acad. Sci. USA., 99, No. 15, 9990-9995 (2002).

    Google Scholar 

  8. M. Antenos, R. F. Casper, T. J. Brown, et al., J. Biol. Chem. 277, No. 16, 44,028-44,034 (2002).

    Google Scholar 

  9. H. Ashida, I. Fukuda, T. Yamashita, and Kanazawa K., FEBS Lett., 476, No. 3, 213-217 (2000).

    Google Scholar 

  10. C. A. Bradfield, E. Glover, and A. Poland, Mol. Pharmacol., 39, 13-19 (1991).

    Google Scholar 

  11. D. B. Carlson and G. H. Perdew, J._Biochem. Mol. Toxicol., 16 317-325 (2002).

    Google Scholar 

  12. R. F. Casper, M. Quesne, I. M. Rogers, et al., Mol. Pharmacol., 56, 784-790 (1999).

    Google Scholar 

  13. H. P. Ciolino, P. J. Daschner, and G. C. Yeh, Biochem. J., 340, 715-722 (1999).

    Google Scholar 

  14. H. P. Ciolino and G. C. Yeh, Br. J. Cancer, 79, 340-346 (1999).

    Google Scholar 

  15. M. S. Denison, J. M. Fisher, and Jr. J. P. Whitlock, J. Biol. Chem., 264, 16,478-16,482 (1989).

    Google Scholar 

  16. M.S. Denison and S. R. Nagy, Annu. Rev. Pharmacol. Toxicol., 43, 309-334 (2003).

    Google Scholar 

  17. M. S. Denison, L. M. Vella, and A. B. Okey, Arch. Biochem. Biophys., 252, 388-395 (1987).

    Google Scholar 

  18. O. Dohr, R. Sinning, C. Vogel, et al., Mol. Pharmacol., 51, 703-710 (1997).

    Google Scholar 

  19. A. Drewnowski and C. Gomez-Cameros, Am. J. Clin. Nutr., 72, 1424-1435 (2000).

    Google Scholar 

  20. C. Elbi, T. Misteli, and G. L. Hager, Mol. Biol. Cell., 13, 2001-2015 (2002).

    Google Scholar 

  21. M. H. Falahatpisheh and K. S. Ramos, Oncogene, 22, 2160-2171 (2003).

    Google Scholar 

  22. P. M. Fernandez-Salguero, D. M. Hilbert, S. Rudikoff, et al., Toxicol. Appl. Pharmacol., 140, 173-179 (1996).

    Google Scholar 

  23. P. M. Fernandez-Salguero, P. Pineau, D. M. Hilbert, et al., Science, 268, 722-726 (1995).

    Google Scholar 

  24. M. Foroozesh, G. Primrose, Z. Guo, et al., Chem. Res. Toxicol., 10, 91-102 (1997).

    Google Scholar 

  25. S. Garte and K. Sogawa, IARC Sci. Publ., 148, 149-157 (1999).

    Google Scholar 

  26. T. A. Gasiewicz, A. S. Kende, G. Rucci, et al., Biochem. Pharmacol. 52, 787-1803 (1996).

    Google Scholar 

  27. Y. Z. Gu, J. B. Hogenesch, and C. A. Bradfield, Annu. Rev. Pharmacol. Toxicol. 40 519-561 (2000).

    Google Scholar 

  28. J. Gusman, H. Malonne, and G. Atassi, Carcinogenesis 22 1111-1117 (2001).

    Google Scholar 

  29. M. E. Hahn, Chem. Biol. Interact. 141 131-160 (2002).

    Google Scholar 

  30. R. N. Hines, Z. Luo, T. Cresteil, et al., Drug Metabol. Disp., 29, 623-633 (2001).

    Google Scholar 

  31. J. B. Hogenesch, W. K. Chan, V. H. Jackiw, et al., J. Biol. Chem., 272, 8581-8593 (1997).

    Google Scholar 

  32. J. B. Hogenesch, Y. Z. Gu, S. M. Moran, et al., J. Neurosci., 20, RC83 (2000).

    Google Scholar 

  33. K. Horvathova, A. Vachalkova, and L. Novotny, Neoplasma, 48, 435-441 (2001).

    Google Scholar 

  34. E. Ignatowicz and W. Baer-Dubowska, Pol. J. Pharmacol., 53, 557-569 (2001).

    Google Scholar 

  35. M. Ikeda, W. Yu, M. Hirai, et al., Biochem. Biophys. Res. Commun., 275, 493-502 (2000).

    Google Scholar 

  36. Joint FAO/WHO Food Standards Programme, 2002. Codex committee on food additives and contaminants, Thirty-fourth Session, Rotterdam, The Netherlands, 11-15 March 2002. Rotterdam (2002).

  37. S. I. Karchner, D. G. Franks, W. H. Powell, et al., J. Biol. Chem., 277, 6949-6959 (2002).

    Google Scholar 

  38. J. E. Kiester and T. A. Gasiewicz, Arch. Biochem. Biophys., 252, 606-625 (1987).

    Google Scholar 

  39. S. K. Kolluri, C. Weiss, A. Koff, et al., Genes Dev., 13, 1742-1753 (1999).

    Google Scholar 

  40. S. Konig, J. Burkman, and J. Fitzgerald, J. Biol. Chem., 277, 27,593-27,605 (2002).

    Google Scholar 

  41. G. P. Lahvis, S. L. Lindell, R. S. Thomas, et al., Proc. Natl. Acad. Sci. USA, 97, 10,442-10,447 (2000).

    Google Scholar 

  42. J. P. Landers and N. J. Bunce, Biochem. J., 276, 273-287 (1991).

    Google Scholar 

  43. P. Langcake and R. G. Pryce, Physiol. Plant Pathol., 9, 77-86 (1976).

    Google Scholar 

  44. Y.-F. Lu, M. Santostefano, B. D. M. Gunningham, et al., Biochem. Pharmacol., 51, No. 8, 1077-1087 (1996).

    Google Scholar 

  45. Q. Ma and K. T. Baldwin, J. Biol. Chem., 275, 8432-8438 (2000).

    Google Scholar 

  46. J. Micka, A. Milatovich, A. Menon, et al., Pharmacogenetics 7, 95-105(1997).

    Google Scholar 

  47. E. Jr. Middleton, C. Kandaswami, and C. Theoharides, Pharmacol. Rev., 52, 673-751 (2000).

    Google Scholar 

  48. J. Mimura and Y. Fujii-Kuriyama, Biochim. Biophys. Acta, 1619, No. 3, 263-268 (2003).

    Google Scholar 

  49. J. Muntane-Relat, J. C. Ourlin, J. Domergue, et al., Hepatology, 22, 1143-1153 (1995).

    Google Scholar 

  50. D. W. Nebert, Crit. Rev. Toxicol., 20, No. 3, 153-174 (1989).

    Google Scholar 

  51. D. W. Nebert, Biochem. Pharmacol., 47, No. 1, 25-37 (1994).

    Google Scholar 

  52. D. W. Nebert and J. J. Duffy, Biochem. Pharmacol., 53, 249-254 (1997).

    Google Scholar 

  53. D. W. Nebert, A. Puga, and V. Vasiliou, Ann. N.Y. Acad. Sci., 685, 624-640 (1993).

    Google Scholar 

  54. S. Nonomura, H. Kanagawa, and A. Makimoto, Yakugaku Zasshi., 83, 983-988 (1963).

    Google Scholar 

  55. J. A. T. Pennington, J. Food Comp. Analys., 15, 419-434 (2002).

    Google Scholar 

  56. A. Poland and J. C. Knutson, Annu. Rev. Pharmacol. Toxicol., 22, 517-554 (1982).

    Google Scholar 

  57. L. C. Quattrochi, T. Vu, R. H. Tukey, J. Biol. Chem., 269, 6949-6954 (1994).

    Google Scholar 

  58. J. J. Reiners, R. Clift, and P. Mathieu, Carcinogenesis, 20, 1561-1566 (1999).

    Google Scholar 

  59. M. S. Ricci, D. G. Toscano, C. J. Mattingly, et al., J. Biol. Chem., 274, 3430-3438 (1999).

    Google Scholar 

  60. S. P. Rivera, T. Saarikoski, O. Hankinson, Mol. Pharmacol., 61, 255-259 (2002).

    Google Scholar 

  61. S. Safe, Toxicol. Lett., 120, 1-7 (2001).

    Google Scholar 

  62. A. Schecter, Dioxins and Health, Ed. A. Schecter, New York (1994), pp. 449-486.

  63. J. V. Schmidt and C. A. Bradfield, Annu. Rev. Cell Dev. Biol., 12, 55-89 (1996).

    Google Scholar 

  64. J. V. Schmidt, G. H. Su, J. K. Reddy, et al., Proc. Natl. Acad. Sci. USA, 93, 6731-6736 (1996).

    Google Scholar 

  65. E. H. Siemann and L. L. Creasy, Am. J. Enol. Vitic., 43, 49-52 (1992).

    Google Scholar 

  66. T. Swain, The Flavonoids, Eds. J.B.Harborne et al., London (1975), pp. 109-1129.

  67. Y. Tsuchiya, M. Nakajima, S. Itoh, et al., Toxicol. Sci., 72, 253-259 (2003).

    Google Scholar 

  68. D. J. Waxman, Arch. Biochem. Biophys., 369, 11-23 (1999).

    Google Scholar 

  69. Jr. J. P. Whitlock, Annu. Rev. Pharmacol. Toxicol., 39, 103-125(1999).

    Google Scholar 

  70. A. Wilhelmson, M. L. Whitelaw, J.-A. Gustafsson, et al., J. Biol. Chem., 269, 19,028-19,033 (1994).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Russian Academy of Medical Sciences, Institute of Nutrition, Russia

    V. A. Tutel'yan, M. M. Gapparov, L. Yu. Telegin, V. M. Devichenskii & L. A. Pevnitskii

  2. Center for Theoretical Problems of Physicochemical Pharmacology, Russian Academy of Sciences, Russia

    V. A. Tutel'yan, M. M. Gapparov, L. Yu. Telegin, V. M. Devichenskii & L. A. Pevnitskii

  3. Department of Clinical Laboratory Diagnostics, Institute for Postgraduate Education, Federal Department of Medical, Biological, and Extreme Problems, Russian Ministry of Health, Russia

    V. A. Tutel'yan, M. M. Gapparov, L. Yu. Telegin, V. M. Devichenskii & L. A. Pevnitskii

  4. Medical-and-Genetic Research Center, Russian Academy of Medical Sciences, Moscow

    V. A. Tutel'yan, M. M. Gapparov, L. Yu. Telegin, V. M. Devichenskii & L. A. Pevnitskii

Authors
  1. V. A. Tutel'yan
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. M. Gapparov
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. L. Yu. Telegin
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. V. M. Devichenskii
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. L. A. Pevnitskii
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Tutel'yan, V.A., Gapparov, M.M., Telegin, L.Y. et al. Flavonoids and Resveratrol as Regulators of Ah-Receptor Activity: Protection from Dioxin Toxicity. Bulletin of Experimental Biology and Medicine 136, 533–539 (2003). https://doi.org/10.1023/B:BEBM.0000020196.18460.99

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/B:BEBM.0000020196.18460.99

  • dioxin
  • Ah-receptor
  • antagonists
  • agonists