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Comparative Study of Action Mechanisms of Dimebon and Memantine on AMPA- and NMDA-Subtypes Glutamate Receptors in Rat Cerebral Neurons

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Abstract

Dimebon in low concentrations potentiated activity of AMPA-receptors in rat cerebellar Purkinje neurons, while memantine produced only an insignificant potentiation in a small group of these cells. In cortical neurons of rat brain memantine efficiently blocked NMDA-induced currents in dimebon-insensitive neurons. By contrast, its effect was far weaker in neurons, where the blocking action of dimebon on NMDA-receptors was most pronounced. It was hypothesized that the differences in the effects of memantine and dimebon are determined by their interaction with different sites of NMDA-receptors.

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Authors and Affiliations

  1. Russian Academy of Sciences, Institute of Physiologically Active Substances, Chernogolovka, Moscow Region

    V. V. Grigor'ev, O. A. Dranyi & S. O. Bachurin

Authors
  1. V. V. Grigor'ev
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  2. O. A. Dranyi
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  3. S. O. Bachurin
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Correspondence to V. V. Grigor'ev.

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Grigor'ev, V.V., Dranyi, O.A. & Bachurin, S.O. Comparative Study of Action Mechanisms of Dimebon and Memantine on AMPA- and NMDA-Subtypes Glutamate Receptors in Rat Cerebral Neurons. Bulletin of Experimental Biology and Medicine 136, 474–477 (2003). https://doi.org/10.1023/B:BEBM.0000017097.75818.14

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  • DOI: https://doi.org/10.1023/B:BEBM.0000017097.75818.14

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