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Mouse Lymphosarcomas Sensitive and Resistant to Cyclophosphamide Therapy: Activity of Cathepsins B, L, and D during Various Schemes of Treatment with Cyclophosphamide and SE-Glycan

Bulletin of Experimental Biology and Medicine volume 136, pages 451–454 (2003)Cite this article

Abstract

We measured activities of cysteine (cathepsins B and L) and aspartyl proteinases (cathepsin D) in tumor tissue of mice with sensitive and resistant lymphosarcomas. In cyclophosphamide-resistant lymphosarcoma tissue activities of cathepsins B, L, and D were lower than in cyclophosphamide-sensitive lymphosarcoma. After treatment with cyclophosphamide in high doses enzyme activities in mice with cyclophosphamide-resistant lymphosarcoma increased more significantly than in animals with cyclophosphamide-sensitive lymphosarcoma. Sulfoethylated β-1,3-D-glycan potentiated the effect of cyclophosphamide in mice with both forms of lymphosarcoma. This drug in the lowest dose (10 mg/kg) was most effective.

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Affiliations

  1. Siberian Division of the Russian Academy of Medical Sciences, Institute of Physiology, Novosibirsk

    T. A. Usova, S. Ya. Zhanaeva, G. Kogan, I. Shandula & T. A. Korolenko

  2. Slovak Academy of Sciences, Institute of Chemistry, Bratislava

    T. A. Usova, S. Ya. Zhanaeva, G. Kogan, I. Shandula & T. A. Korolenko

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  1. T. A. Usova
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  2. S. Ya. Zhanaeva
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  3. G. Kogan
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  4. I. Shandula
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  5. T. A. Korolenko
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Usova, T.A., Zhanaeva, S.Y., Kogan, G. et al. Mouse Lymphosarcomas Sensitive and Resistant to Cyclophosphamide Therapy: Activity of Cathepsins B, L, and D during Various Schemes of Treatment with Cyclophosphamide and SE-Glycan. Bulletin of Experimental Biology and Medicine 136, 451–454 (2003). https://doi.org/10.1023/B:BEBM.0000017090.00132.67

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  • DOI: https://doi.org/10.1023/B:BEBM.0000017090.00132.67

  • cathepsins B, L, and D
  • resistant lymphosarcoma
  • glycans