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Effect of Adrenalectomy on Healing of Indomethacin-Induced Gastric Erosions in Rats

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Abstract

We studied the effects of adrenalectomy and replacement therapy on healing of gastric erosions in adult Sprague-Dawley rats developed 4 h after subcutaneous injection of indomethacin in a dose of 25 or 35 mg/kg. Adrenalectomy was performed 1 week before or 4 h after indomethacin administration. Healing was evaluated by changes in the area of erosions over 24 h after indomethacin administration at fixed time intervals. Plasma corticosterone was measured. Adrenalectomy (irrespective of the time of intervention) decelerated healing of gastric injuries. Injection of corticosterone in a physiological dose of 4 mg/kg at the initial stage of healing (4 h after indomethacin administration) improved healing of erosions.

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Authors and Affiliations

  1. Laboratory of Experimental Endocrinology, I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg

    T. T. Podvigina, T. R. Bagaeva, L. P. Filaretova & A. A. Pykholov

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  1. T. T. Podvigina
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  2. T. R. Bagaeva
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  3. L. P. Filaretova
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  4. A. A. Pykholov
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Podvigina, T.T., Bagaeva, T.R., Filaretova, L.P. et al. Effect of Adrenalectomy on Healing of Indomethacin-Induced Gastric Erosions in Rats. Bulletin of Experimental Biology and Medicine 136, 435–437 (2003). https://doi.org/10.1023/B:BEBM.0000017085.18950.87

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  • DOI: https://doi.org/10.1023/B:BEBM.0000017085.18950.87

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