We examined the association between lifetime depression history and sexual function in a community-based sample of midlife women. Specifically, 914 women aged 42-52 who were participants in the Study of Women's Health Across the Nation completed a self-report assessment of their sexual behaviors, sexual desire, sexual arousal, and sexual satisfaction over the past 6 months. On the basis of the Structured Clinical Interview for the DSM-IV, participants were categorized into 1 of 3 lifetime major depressive disorder (MDD) history groups: no MDD history, single episode MDD, and recurrent MDD. In line with previous reports, women with a history of recurrent MDD reported experiencing less frequent sexual arousal, less physical pleasure, and less emotional satisfaction within their current sexual relationships. Although the groups did not differ in their reported frequency of sexual desire or partnered sexual behaviors, lifetime depression history was associated with increased rates of self-stimulation (masturbation). Associations between lifetime depression history and lower levels of physical pleasure within partnered sexual relationships and higher rates of masturbation remained significant following control for current depressive symptoms, study site, marital status, psychotropic medication use, and lifetime history of anxiety or substance abuse/dependence disorder. Future research is needed to characterize the temporal and etiologic relationships among lifetime depressive disorder, current mood state, and sexual function in women across the lifespan.
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Abma, J., Chandra, A., Mosher, W., Peterson, L., & Piccinino, L. (1997). Fertility, family planning, and women's health: New data from the 1995 National Survey of Family Growth. Vital and Health Statistics, 23,1-114.
Avis, N. E. (2000). Is there a relationship between menopause and mood? In R. A. Lobo, J. Kelsey, & R. Marcus (Eds.), Menopause: Biology and pathobiology (pp. 339-352). San Diego, CA: Academic Press.
Baldwin, D. S. (1996). Depression and sexual function. Journal of Psychopharmacology, 10(Suppl. 1), 30-34.
Bancroft, J., Loftus, J., & Long, J. S. (2003). Distress about sex: A national survey of women in heterosexual relationships. Archives of Sexual Behavior, 32,193-208.
Boyd, J. H., Weissman, M. M., Thompson, W. D., & Myers, J. K. (1982). Screening for depression in a community sample: Understanding the discrepancies between depression symptom and diagnostic sales. Archives of General Psychiatry, 39,1195-1200.
Clayton, A. H., McGarvey, E. L., Clavet, G. J., & Piazza, L. (1997). Comparison of sexual functioning in clinical and nonclinical populations using the Changes in Sexual Functioning Questionnaire (CSFQ). Psychopharmacology Bulletin, 33,747-753.
Comstock, G. W., & Helsing, K. J. (1976). Symptoms of depression in two communities. Psychological Medicine, 6,551-563.
Cyranowski, J. M., Frank, E., Cherry, C., Houck, P., & Kupfer, D. J. (2004). Prospective assessment of sexual function in women treated for recurrent major depression. Journal of Psychiatric Research, 38,267-273.
Dunn, K. M., Croft, P. R., & Hackett, G. I. (1999). Association of sexual problems with social, psychological, and physical problems in men and women: A cross sectional population survey. Journal of Epidemiology and Community Health, 53,144-148.
Frohlich, P., & Meston, C. (2002). Sexual functioning and self-reported depressive symptoms among college women. J ournal of Sex Research , 39,321-325.
Gitlin, M. J. (1995). Effects of depression and antidepressants on sexual functioning. Bulletin of the Menninger Clinic, 59,232-248.
Hammen, C., & Brennan, P. A. (2002). Interpersonal dysfunction in depression women: Impairments independent of depressive symptoms. Journal of Affective Disorders, 72,145-156.
Hirschfeld, R. M. A. (1999). Care of sexually active depressed patients. Journal of Clinical Psychiatry, 60(Suppl. 17), 32-35.
Kennedy, S. H., Dickens, S. E., Eisfeld, B. S., & Bagby, R. M. (1999). Sexual dysfunction before antidepressant therapy in major depression. Journal of Affective Disorders, 56,201-208.
Laumann, E. O., Gagnon, J. H., Michael, R. T., & Michaels, S. (1994). The social organization of sexuality: Sexual practices in the United States.Chicago: University of Chicago Press.
Piazza, L. A., Markowitz, J. C., Kocsis, J. H., Leon, A. C., Portera, L., Miller, N. L., et al. (1997). Sexual functioning in chronically depressed patients treated with SSRI antidepressants: A pilot study. American Journal of Psychiatry, 154,1757-1759.
Radloff, L. S. (1977). The CES-D Scale: A self-report depression scale for research in the general population. Applied Psychological Measurement, 1,385-401.
Schreiner-Engel, P., & Schiavi, R. C. (1986). Lifetime psychopathology in individuals with low sexual desire. Journal of Nervous and Mental Disease, 174,646-651.
Soules, O. M. R., Sherman, S., Parrott, E., Rebar, R., Santoro, N., Utian, W., et al. (2001). Executive summary: Stages of Reproductive Aging Workshop (STRAW). Fertility and Sterility, 76,874-878.
Sowers, M., Crawford, S., Sternfeld, B., Morganstein, D., Gold, E., Greendale, G., et al. (2000). SWAN: A multicenter, multiethnic community-based cohort study of women and the menopausal tran-sition. In R. A. Lobo, J. Kelsey, & R. Marcus (Eds.), Menopause: Biology and pathology (pp. 175-188). San Diego, CA: Academic Press.
Spitzer, R. L., Williams, J. B., Gibbon, M., & First, M. B. (1992). The Structured Clinical Interview for DSM-III-R (SCID). I: History, rationale, and description. Archives of General Psychiatry, 49,624-629.
StataCorp. (2003). Stata Statistical Software: Release 8.0.College Station, TX: Stata Corporation.
Williams, J. B., Gibbon, M., First, M. B., Spitzer, R. L., Davies, M., Borus, J., et al. (1992). The Structured Clinical Interview for DSM-III-R (SCID). II. Multisite test-retest reliability. Archives of General Psychiatry, 49,630-636.
Women's Health Initiative Study Group. (1998). Design of the Women's Health Initiative Clinical Trial and Observational Study. Controlled Clinical Trials, 19,61-109.
Zajecka, J., Dunner, D. L., Gelenberg, A. J., Hirschfeld, R. M. A., Kornstein, S. G., Ninan, P. T., et al. (2002). Sexual function and satisfaction in the treatment of chronic major depression with nefazodone, psychotherapy, and their combination. Journal of Clinical Psychiatry, 63,709-716.
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Cyranowski, J.M., Bromberger, J., Youk, A. et al. Lifetime Depression History and Sexual Function in Women at Midlife. Arch Sex Behav 33, 539–548 (2004). https://doi.org/10.1023/B:ASEB.0000044738.84813.3b
- sexual behavior
- sexual satisfaction
- Study of Women's Health Across the Nation