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Sonorheometry: A Noncontact Method for the Dynamic Assessment of Thrombosis

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Abstract

Inappropriate blood coagulation plays a central role in the onset of myocardial infarction, stroke, pulmonary embolism, and other thrombotic disorders. The ability to screen for an increased propensity to clot could prevent the onset of such events by appropriately identifying those at risk and enabling prophylactic treatment. Similarly, the ability to characterize the mechanical properties of clots in vivo might improve patient outcomes by better informing treatment strategies. We have developed a technique called sonorheometry. Unlike existing methods, sonorheometry is able to assess mechanical properties of coagulation with minimal disturbance to the delicate structure of a forming thrombus. Sonorheometry uses acoustic radiation force to produce small, localized displacements within the sample. Time delay estimation is performed on returned ultrasound echoes to determine sample deformation. Mechanical modeling and parametric fitting to experimental data yield maps of mechanical properties. Sonorheometry is well suited to both in vitro and in vivo applications. A control experiment was performed to verify that sonorheometry provides mechanical characterization in agreement with that from a conventional rheometer. We also examined thrombosis in blood samples taken from four subjects. This data suggests that sonorheometry may offer a novel and valuable method for assessing the thrombogenicity of blood samples.

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REFERENCES

  1. Anderson, F. A., and A.-M. Audet. Best Practices: Preventing Deep Vein Thrombosis and Pulmonary Embolism. Center for Outcomes Research, U MassMed Center, 1998.

  2. Emelianov, S. Y., J. M. Rubin, X. Chen, A. R. Skovoroda, T. W. Wakefield, and M. O'Donnell. Ultrasound elasticity imaging of deep vein thrombosis. Proc. IEEE Ultrason. Symp. 1791-1794, 2000.

    Google Scholar 

  3. Harris, J. M., and N. Abramson. Evaluation of recurrent thrombosis and hypercoagulability. Am. Fam. Physician 56, Oct. 15, 1997.

    Google Scholar 

  4. Hartley, C. J. Characteristics of acoustic streaming created and measured by pulsed Doppler ultrasound. IEEE Trans. Ultrason., Ferroelectrics, Frequency Control 44:1278–1285, 1997.

    Google Scholar 

  5. Hirsch, J., and J. Hoak. Management of deep vein thrombosis and pulmonary embolism. A statement for healthcare professionals. Council of Thrombosis, American Heart Association. Circulation 93:2212–2245, 1996.

    Google Scholar 

  6. Hirsh, J., and A. Y. Lee. How we diagnose and treat deep vein thrombosis. Blood 99:3102–3110.

  7. Jensen, J. A., and N. B. Svendsen. Calculation of pressure fields from arbitrarily shaped, apodized, and excited ultrasound transducers. IEEE Trans. Ultrason., Ferroelectrics, Frequency Control 39:262–267, 1992.

    Google Scholar 

  8. Nightingale, K. R., R. Nightingale, D. Stutz, and G. E. Trahey. Acoustic radiation force impulse imaging of in vivo vastus medialis muscle under varying isometric load. Ultrason. Imaging 24:100–108, 2002.

    Google Scholar 

  9. Nightingale, K. R., M. S. Soo, R. Nightingale, R. Bentley, and G. E. Trahey. In vivo demonstration of acoustic radiation force impulse (ARFI) imaging in the thyroid, abdomen, and breast. Proc. IEEE Ultrason. Symp. 1627–1631, 2002.

  10. Nightingale, K. R., M. S. Soo, R. Nightingale, and G. E. Trahey. Acoustic radiation force impulse imaging: In vivo demonstration of clinical feasibility. Ultrasound Med. Biol. 28:227–235, 2002.

    Google Scholar 

  11. Parsons, R. E., B. Sigel, E. J. Feleppa, R. M. Golub, I. Kodama, L. A. Loiacono, J. Justin, V. K. Swami, H. Kimitsuki, M. Rorke, M. M. Yaremko, C. D. Long, A. Can, and F. L. Lizzi. Age determination of experimental venous thrombi by ultrasonic tissue characterization. J. Vasc. Surg. 17:470–478, 1993.

    Google Scholar 

  12. Shung, K. K., D. Fei, Y. Yuan, and W. C. Reeves. Ultrasonic characterization of blood during coagulation. J. Clin. Ultrasound 12:147–153, 1984.

    Google Scholar 

  13. Viola, F., and W. F. Walker. A comparison of the performance of time delay estimators in medical ultrasound. IEEE Trans. Ultrason., Ferroelectrics, Frequency Control 50:392–401, 2003.

    Google Scholar 

  14. Viola, F., and W. F. Walker. Radiation force imaging of viscoelastic properties with reduced artifacts. IEEE Trans. Ultrason., Ferroelectrics, Frequency Control 50:736–742, 2003.

    Google Scholar 

  15. Visit the following link for a list of tests commonly performed by laboratories: http://repro-med.net/papers/thromb.html

  16. Walker, W. F., F. J. Fernandez, and L. A. Negron. A method of imaging viscoelastic parameters with acoustic radiation force. Phys. Med. Biol. 45:1437–1447, 2000.

    Google Scholar 

  17. Webster, J. G. Medical Instrumentation: Application and Design. New York: Wiley, 1998, p. 33.

    Google Scholar 

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Viola, F., Kramer, M.D., Lawrence, M.B. et al. Sonorheometry: A Noncontact Method for the Dynamic Assessment of Thrombosis. Annals of Biomedical Engineering 32, 696–705 (2004). https://doi.org/10.1023/B:ABME.0000030235.72255.df

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  • DOI: https://doi.org/10.1023/B:ABME.0000030235.72255.df

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