Plant Foods for Human Nutrition

, Volume 58, Issue 3, pp 1–7 | Cite as

Effects of parsley (Petroselinum crispum) on the aorta and heart of Stz induced diabetic rats

  • Göksel Sener
  • Özlem Saçan
  • Refiye Yanardag
  • Gül Ayanoglu-Dülger
Article

Abstract

Parsley is one of the medicinal herbs used by diabetics in Turkey. It has been reported to reduce blood glucose levels. In this study the effects of feeding parsley on diabetes-induced free radical mediated injury in rat aorta and heart tissues were investigated. Swiss albino rats were divided into six groups: Control, diabetic, parsley, diabetic + parsley, glibornurid, and diabetic + glibornurid. Rats were subjected to i.p. streptozotocin (STZ, 65 mg/kg) to induce diabetes. On the fourteenth day of the study, either parsley (2 g/kg) or glibornurid (5 mg/kg) were given for 28 days to the diabetic rats. Aorta and heart tissue lipid peroxidation and glutathione levels as well as blood glucose levels were determined. The results of the present study indicate that lipid peroxidation was increased and glutathione levels were decreased in both aorta and heart tissue of the diabetic rats. However, treatment of the diabetic rats with either parsley or glibornurid reversed the effects of diabetes on blood glucose, and tissue lipid peroxidation and glutathione levels.

glutathione lipid peroxidation parsley streptozotocin 

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Copyright information

© Kluwer Academic Publishers 2003

Authors and Affiliations

  • Göksel Sener
    • 1
  • Özlem Saçan
    • 2
  • Refiye Yanardag
    • 2
  • Gül Ayanoglu-Dülger
    • 1
  1. 1.Department of Pharmacology, Faculty of PharmacyMarmara Universityİstanbul-Turkey
  2. 2.Department of Chemistry, Faculty of Engineeringİstanbul UniversityAvcıİstanbul-Turkey

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