Pharmaceutical Research

, Volume 21, Issue 1, pp 185–188 | Cite as

Solid-State Nuclear Magnetic Resonance Determination of the Physical Form of BHA on Common Pharmaceutical Excipients

  • Julius F. Remenar
  • Robert Wenslow
  • Drazen Ostovic
  • Andrey PeresypkinEmail author


Purpose. The purpose of this study was to evaluate the physical form of 2-tert-butyl-4-methoxy-phenol (BHA) following wet granulation onto common pharmaceutical excipients.

Methods. A 13C label was incorporated into the methoxy group of BHA, the major isomer in synthetic butylated hydroxyanisole. Solutions of the labeled BHA were used to load the labeled BHA onto common pharmaceutical excipients. After air drying under ambient conditions, the mixtures were examined by 13C MAS and CP/MAS nuclear magnetic resonance (NMR) spectroscopy to evaluate the physical form of the BHA.

Results. The data suggested that BHA could exist as either a crystalline or an amorphous component and that amorphous material was either bound to excipients or relatively mobile during the time of the NMR experiment. At 0.1% loading, BHA appeared to be amorphous and mobile in the freshly prepared blends. At 0.5% loading, BHA was shown to be amorphous on microcrystalline cellulose (MCC) and hydroxypropylmethylcellulose (HPMC) while remaining crystalline on lactose, mannitol, calcium phosphate dihydrate, and croscarmellose sodium.

Conclusions. Solid-state NMR spectroscopy has been used to probe the physical forms of 13C-labeled BHA granulated onto common pharmaceutical excipients. The techniques described in this paper may be applied to help explain stability changes in formulations containing BHA.

amorphous crystalline mobile nuclear magnetic resonance (NMR) 2-tert-butyl-4-methoxy-phenol (BHA) 


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Copyright information

© Plenum Publishing Corporation 2004

Authors and Affiliations

  • Julius F. Remenar
    • 1
  • Robert Wenslow
    • 2
  • Drazen Ostovic
    • 2
  • Andrey Peresypkin
    • 3
    Email author
  1. 1.Transform PharmaceuticalsLexington
  2. 2.Merck & Co.Rahway
  3. 3.Merck & Co.Rahway

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