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Carbonylation of α-Haloketones

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Abstract

The catalytic carbonylation reactions of α-haloketones in the presence of palladium compounds were studied. Chloroketones were selectively converted into β-ketoesters, whereas bromoacetophenone was partially reduced to acetophenone. The reaction rate at atmospheric pressure was much lower than that at an elevated pressure. A reaction mechanism was proposed.

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Lapidus, A.L., Eliseev, O.L., Bondarenko, T.N. et al. Carbonylation of α-Haloketones. Kinetics and Catalysis 45, 234–238 (2004). https://doi.org/10.1023/B:KICA.0000023797.89865.e5

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  • DOI: https://doi.org/10.1023/B:KICA.0000023797.89865.e5

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