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Thermoanalytical characterization of potentially schistosomicide polymeric derivatives

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Abstract

Oxamniquine (OXA) is a schistosomicide agent that causes some adverse effects in central nervous system. Intending to improve OXA therapeutic properties, a polymeric prodrug was designed. Currently, there is an increasing interest of thermal analytical techniques in the pharmaceutical area, so differential thermal analysis (DTA) and thermogravimetry (TG) were carried out to evaluate the thermal behavior of OXA, polymethacrylic acid (PMA), [poly(methacrylic-co-oxamniquine methacrylate)acid] (PMOXA) and physical mixture (OXA+PMA). The thermoanalytical profile of the physical mixture showed characteristic events of the thermal decomposition of OXA and PMA. Distinctly, PMOXA DTA curve did not show an endothermic peak at 148.5°C indicating that the drug was incorporated into the polymeric system. These results were corroborated by the IR spectroscopy and X-ray diffraction data.

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Authors and Affiliations

  1. Department of Pharmacy, Faculty of Pharmaceutical Science of the USP/SP, Av. Professor Lineu Prestes, 580, Săo Paulo/, SP, CEP 05508-910, C.P. 66083, Brazil

    R. Parise Filho & M. A. B. Silveira

  2. Department of Fundamental Chemistry, Institute of Chemistry of the USP/SP, Brazil

    A. A. S. Araújo & J. R. Matos

  3. Oxiteno S/A - Commercial and Industry, Brazil

    M. Santos Filho

  4. Butantan Institute, Brazil

    C. A. Brandt

Authors
  1. R. Parise Filho
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  2. A. A. S. Araújo
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  3. M. Santos Filho
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  4. J. R. Matos
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  5. M. A. B. Silveira
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  6. C. A. Brandt
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Parise Filho, R., Araújo, A.A.S., Santos Filho, M. et al. Thermoanalytical characterization of potentially schistosomicide polymeric derivatives. Journal of Thermal Analysis and Calorimetry 75, 487–494 (2004). https://doi.org/10.1023/B:JTAN.0000027137.43662.de

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  • DOI: https://doi.org/10.1023/B:JTAN.0000027137.43662.de

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