Skip to main content
SpringerLink
Log in

Cyclotron production and quality control of “high specific activity' radionuclides in “no-carrier-added” form for radioanalytical applications in the life sciences

  • Published:
Journal of Radioanalytical and Nuclear Chemistry Aims and scope Submit manuscript

Abstract

Radionuclides of very high specific activity A S(t) have great relevance for applications in the life sciences. Updated definitions of A S are given. The real A S(t) must be measured by analytical and radioanalytical techniques. No-carrier-added (NCA) radionuclides have A S(NCA) sometimes close to the carrier-free (CF) value A S(CF). The accurate knowledge of excitation functions of nuclear reactions vs. ion beam energy is mandatory to maximize A S(NCA); the minimization of isotopic dilution factor IDF(t) has been achieved too. A range of accelerator production and radioanalytical QC methods for A S(NCA) optimization and determination is presented.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. E. Sabbioni, L. GÖtz, C. Birattari, M. Bonardi, Sci. Total Environ., 17 (1981) 257.

    Article  CAS  Google Scholar 

  2. M. Bonardi, F. Groppi, H. S. Mainardi, Microchem. J., 73 (2002) 153.

    Article  CAS  Google Scholar 

  3. M. Bonardi, C. Birattari, F. Groppi, E. Sabbioni, Appl. Radiation Isotopes, 57/5 (2002) 617.

    Article  Google Scholar 

  4. An. N. Nesmeyanov, Radiochemistry, MIR Publishers, Moscow, 1974.

    Google Scholar 

  5. K. H. Lieser, Nuclear and Radiochemistry: Fundamentals and Applications, 2nd revised ed., Wiley and Verlag, VHC, Berlin, 2001.

    Google Scholar 

  6. A. P. Wolf, T. J. Tewson, M. J. Welch, J. Nucl. Med., 22 (1981) 392.

    Google Scholar 

  7. D. Basile, C. Birattari, M. Bonardi, L. GÖtz, E. Sabbioni, A. Salomone, Intern. J. Appl. Radiation Isotopes, 32 (1981) 403.

    Article  CAS  Google Scholar 

  8. E. Sabbioni, M. Bonardi, Li Da-Kang, M. Gallorini, B. Weckermann, M. Castiglioni, J. Radioanal. Nucl. Chem., 134 (1989) 199.

    Article  CAS  Google Scholar 

  9. E. Sabbioni, M. Bonardi, M. Gallorini, R. Pietra, S. Fortaner, G. P. Tartaglia, F. Groppi, J. Radioanal. Nucl. Chem., 160 (1992) 549.

    Article  Google Scholar 

  10. M. Bonardi, M. Gallorini, F. Groppi, L. Magon, A. Marchi, S. Saponaro, L. Ulrici, J. Radioanal. Nucl. Chem., 195 (1995) 227.

    Article  CAS  Google Scholar 

  11. M. Bonardi, M. Gallorini, F. Groppi, S. Saponaro, Microchem. J., 51 (1995) 278.

    Article  CAS  Google Scholar 

  12. M. Bonardi, C. Birattari, M. Gallorini, F. Groppi, D. Arginelli, L. Gini, J. Radioanal. Nucl. Chem., 236 (1998) 159.

    Article  CAS  Google Scholar 

  13. F. Groppi, M. Bonardi, C. Birattari, M. Gallorini, L. Gini, J. Radioanal. Nucl. Chem., 249 (2001) 289.

    Article  CAS  Google Scholar 

  14. M. Bonardi, F. Groppi, C. Birattari, D. Arginelli, Ann. Chim., 92 (2002) 795.

    CAS  Google Scholar 

  15. F. Groppi, C. Birattari, M. Bonardi, L. Gini, Microchem. J., 73 (2002) 203.

    Article  CAS  Google Scholar 

  16. M. J. Welch, C. S. Redvanly (Eds), Handbook of Radiopharmaceuticals: Radiochemistry and Applications, John Wiley and Sons, New York, 2003.

    Google Scholar 

  17. I. Mills, T. CvitaŠ, K. Loman, N. Kallay, K. Kuchitsu (Eds), IUPAC Physical Chemistry Division, Quantities, Units and Symbols in Physical Chemistry, 2nd ed., Blackwell Scientific Publications, Oxford, 1993.

    Google Scholar 

  18. J. InczÉdy, T. Lengyel, A. M. Ure, A. GelencsÉr, A. Hulanicki (Eds), Radioanalytical Methods, Chapter 16, in: IUPAC Compendium of Analytical Nomenclature, Definitive Rules 1997, 3rd ed., 2000.

  19. J. Ruzicka, J. Stary, Substoichiometry in Radiochemical Analysis, Intern. Series of Monographs in Analytical Chemistry, Vol. 30, Pergamon Press, Oxford, 1968.

    Google Scholar 

  20. J. TÖlgyessy, T. Braun, M. KÝrs, Isotope Dilution Analysis, Pergamon Press, Oxford, 1972.

    Google Scholar 

  21. M. Bonardi, C. Birattari, J. Radioanal. Chem., 76 (1983) 311.

    CAS  Google Scholar 

  22. M. Bonardi, The contribution to nuclear data for medical radioisotope production from the Milan Cyclotron Laboratory, IAEA Consultant's Meeting on “Nuclear Data Requirements for Medical Radioisotope Production”, Tokyo, April 1987, IAEA INDC(NDS)-195/GZ, Vienna, Austria, January 1988, p. 98.

    Google Scholar 

  23. TECDOC-1211, Charged-particle cross-section database for medical radioisotope production. Co-ordinated Research Project (1995–1999), IAEA, Vienna, May 2001. Available online at: http://www-nds.iaea.org/medical/

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Radiochemistry Laboratory, LASA, Universita degli Studi and National Institute of Nuclear Physics, INFN via F.lli Cervi 201, I-20090, Segrate, Milano, Italy

    M. L. Bonardi, C. Birattari, F. Groppi, L. Gini & H. S. C. Mainardi

Authors
  1. M. L. Bonardi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. C. Birattari
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. F. Groppi
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. L. Gini
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. H. S. C. Mainardi
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Bonardi, M.L., Birattari, C., Groppi, F. et al. Cyclotron production and quality control of “high specific activity' radionuclides in “no-carrier-added” form for radioanalytical applications in the life sciences. Journal of Radioanalytical and Nuclear Chemistry 259, 415–419 (2004). https://doi.org/10.1023/B:JRNC.0000020910.81704.9b

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/B:JRNC.0000020910.81704.9b

Keywords

Search

Navigation