Journal of Bioenergetics and Biomembranes

, Volume 35, Issue 6, pp 577–598

Modulation and Pharmacology of Low Voltage-Activated (“T-Type”) Calcium Channels

  • Anne Marie R. Yunker

DOI: 10.1023/B:JOBB.0000008025.65675.37

Cite this article as:
Yunker, A.M.R. J Bioenerg Biomembr (2003) 35: 577. doi:10.1023/B:JOBB.0000008025.65675.37


Although T-type calcium channel currents were observed almost 30 years ago, the genes that encode the pore-forming subunits have only been recently reported. When expressed in heterologous systems, three distinct alpha1 subunits (alpha1G (Cav3.1), alpha1H (Cav3.2), and alpha1I (Cav3.3)) conduct T-type currents with insert similar but not identical electrophysiological characteristics that. Alpha1G, alpha1H, and alpha1I transcripts are found throughout neural and nonneural tissues, suggesting multiple types of T-type channels (also called low voltage-activated calcium channels (LVAs)) are coexpressed by many tissues. The study of endogenous LVAs has been hampered by a lack of highly selective antagonists that differentiate between LVA subtypes. Furthermore, many pharmacological agents attenuate currents conducted by LVA and high voltage-activated calcium channels (HVAs). At least 15 classes of pharmacological agents affect T-type currents, and the therapeutic use of many of these drugs has implicated LVAs in the etiology of a variety of diseases. Comparison of the responses of recombinant and native LVAs to pharmacological agents and endogenous modulatory molecules will lead to a better understanding of LVAs in normal and diseased cells.

T-type review alpha1G (Cav3.1) alpha1H (Cav3.2) alpha1I (Cav3.3) epilepsy cardiac vascular pharmacology 

Copyright information

© Plenum Publishing Corporation 2003

Authors and Affiliations

  • Anne Marie R. Yunker
    • 1
  1. 1.Department of General Medical Sciences, E620 School of MedicineCase Western Reserve University School of MedicineCleveland

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