Journal of Analytical Chemistry

, Volume 59, Issue 3, pp 288–290 | Cite as

Electrochemical Determination of Lipoic Acid

  • G. K. Ziyatdinova
  • G. K. Budnikov
  • V. I. Pogorel'tsev


Procedures for determining lipoic acid by voltammetry and coulometric titration with electrogenerated halogens using the biamperometric indication of the titration end-point were developed. Possible mechanisms of lipoic acid oxidation with electrogenerated halogens are discussed. Microgram amounts of lipoic acid were determined in model solutions with an RSD of 1–2%. The analytical range of lipoic acid found by voltammetry at a glassy-carbon electrode lies between 1.15 × 10–5 and 1.73 × 10–4 M. The detection limit for lipoic acid is 5.75 × 10–6 M.


Oxidation Analytical Chemistry Titration Detection Limit Halogen 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Shul'pekova, Yu.O. and Ivashkin, V.T., Ross. Med. Zh., 2000, vol. 8, nos. 15-16, p. 630.Google Scholar
  2. 2.
    Bast, A. and Haenen, G.R.M.M., Biochim. Biophys. Acta, 1988, vol. 963, p. 558.Google Scholar
  3. 3.
    Packer, L., Wit, E.H., and Tritschler, H.J., Free Radical Biol. Med., 1995, vol. 19, no. 2, p. 227.Google Scholar
  4. 4.
    Nickander, K.K., McPhee, B.R., Low, P.A., and Tritschler, H., Free Radical Biol. Med., 1996, vol. 21, no. 5, p. 631.Google Scholar
  5. 5.
    Kataoka, H., Hirabayashi, N., and Makita, M., Trends Anal. Life Sci., 1997, vol. 1, no. 1, p. 63.Google Scholar
  6. 6.
    Podda, M., Tritschler, H.J., Ulrich, H., and Packer, L., Biochem. Biophys. Res. Commun., 1994, vol. 204, p. 98.Google Scholar
  7. 7.
    Kagan, V., Khan, S.M., Swanson, C., Shvedova, A., Serbinova, E., and Pacher, L., Free Radical Biol. Med., 1990, vol. 9, no. 1, p. 15.Google Scholar
  8. 8.
    Hajyehia, A.I., Assaf, P., Nassar, T., and Katzhendler, J., J. Chromatogr., 2000, vol. 870, nos. 1-2, p. 381.Google Scholar

Copyright information

© MAIK “Nauka/Interperiodica” 2004

Authors and Affiliations

  • G. K. Ziyatdinova
    • 1
  • G. K. Budnikov
    • 1
  • V. I. Pogorel'tsev
    • 2
  1. 1.Department of ChemistryKazan State UniversityTatarstanRussia
  2. 2.Kazan State Medical UniversityTatarstanRussia

Personalised recommendations