Chemistry of Heterocyclic Compounds

, Volume 40, Issue 7, pp 888–894 | Cite as

Cyclocondensation of 2-Fluoro-5-nitrobenzaldehyde with Amidines. New Synthesis of Isoquinolines

  • D. V. Dar'in
  • S. I. Selivanov
  • P. S. Lobanov
  • A. A. Potekhin


The direction of the cyclocondensation of 2-fluoro-5-nitrobenzaldehyde with five amidines having α-hydrogen atoms has been studied. It was established that depending on the structure of the amidine the main products of the reaction may be not only quinazolines but also 3-aminoisoquinolines. A new convenient route has been found for the synthesis of 3-aminoisoquinolines consisting of the cyclocondensation of α-acylacetamidines with 2-fluoro-5-nitrobenzaldehyde.

amidines as N,N- and C,N-dinucleophiles isoquinolines 2-fluoro-5-nitrobenzaldehyde cyclocondensation 


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Copyright information

© Plenum Publishing Corporation 2004

Authors and Affiliations

  • D. V. Dar'in
  • S. I. Selivanov
  • P. S. Lobanov
  • A. A. Potekhin

There are no affiliations available

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