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Model compounds for galactose oxidase: The crystal and molecular structure of dimeric (4-methylpyridine-N) (N-salicylidene-tyrosinato-O, N, O′)copper(II)

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Abstract

Galactose oxidase is a type II copper protein that contains a square–pyramidal five-coordinate copper center and catalyzes the oxidation of primary alcohols to aldehydes with a concomitant reduction of molecular oxygen. Dimeric (4-methylpyridine-N)(N-salicylidene-tyrosinato-O, N, O′)copper(II), which contains two square–pyramidal five-coordinate copper centers and thus serves as a model for galactose oxidase, crystallizes in the monoclinic space group P2 1/c with a = 8.914(1) Å, b = 18.415(2) Å, c = 12.802(2) Å, β = 107.70(1)°. The dinuclear unit comprises two four-coordinate units each consisting of the tridentate Schiff base and 4-methylpyridine with a weaker out-of-plane link to the phenolic oxygen atom from the adjoining unit in a typical 4 + 1 distorted square–pyramidal geometry.

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Authors and Affiliations

  1. Department of Chemistry, Howard University, 525 College Street NW, Washington, District of Columbia, 20059

    Ray J. Butcher

  2. Department of Chemistry, University of Wollongong, Wollongong, NSW, 2522, Australia

    Owen McKern & Garry M. Mockler

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  1. Ray J. Butcher
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  2. Owen McKern
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  3. Garry M. Mockler
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Correspondence to Ray J. Butcher.

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Butcher, R.J., McKern, O. & Mockler, G.M. Model compounds for galactose oxidase: The crystal and molecular structure of dimeric (4-methylpyridine-N) (N-salicylidene-tyrosinato-O, N, O′)copper(II). Journal of Chemical Crystallography 33, 891–895 (2003). https://doi.org/10.1023/A:1027466014969

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  • DOI: https://doi.org/10.1023/A:1027466014969

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