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The GS-X Pump in Plant, Yeast, and Animal Cells: Structure, Function, and Gene Expression

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Bioscience Reports

Abstract

This review addresses the recent molecular identification of several members of the glutathione S-conjugate (GS-X) pump family, a new class of ATP-binding cassette (ABC) transporters responsible for the elimination and/or sequestration of pharmacologically and agronomically important compounds in mammalian, yeast and plant cells. The molecular structure and function of GS-X pumps encoded by MRP, cMOAT, YCF1. and AtMRP genes, have been conserved throughout molecular evolution. The physiologic function of GS-X pumps is closely related with cellular detoxification, oxidative stress, inflammation, and cancer drug resistance. Coordinated expression of GS-X pump genes, e.g., MRP1 and YCF1, and γ-glutamylcystaine synthetase, a rate-limiting enzyme of cellular glutathione (GSH) biosynthesis, has been frequently observed.

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  1. Department of Medicinal Biology, Central Research, Pfizer Inc., 5-2 Taketoyo, Aichi, 470-23, Japan

    Toshihisa Ishikawa

  2. Plant Science Institute, Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania, 19104-6018

    Ze-Sheng Li, Yu-Ping Lu & Philip A. Rea

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  1. Toshihisa Ishikawa
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Ishikawa, T., Li, ZS., Lu, YP. et al. The GS-X Pump in Plant, Yeast, and Animal Cells: Structure, Function, and Gene Expression. Biosci Rep 17, 189–207 (1997). https://doi.org/10.1023/A:1027385513483

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