Abstract
The purpose of the study was to investigate the prevalence of gastric lesions and to provide diagnostic values for serum pepsinogen in non-infected pigs and in pigs with gastric disease. In an abattoir survey, the pepsinogen concentrations were measured in the serum from 62 non-infected pigs, 33 pigs with gastric lesions and 17 pigs infected with Hyostrongylus rubidus, using a specific radioimmunoassay (RIA). The mean (±SE) pepsinogen concentrations in the serum of non-infected pigs, in pigs with gastric ulcers, and in pigs with a heavy H. rubidus infection were 630.8±39.2 ng/ml, 1084.5±166.2 ng/ml and 1095.2±102.3 ng/ml, respectively (p<0.05). Because of the higher concentrations of pepsinogen in the blood of pigs with gastric ulcers or parasitic infections, it is suggested that the measurement of serum pepsinogen by RIA may be an effective biochemical approach to the diagnosis of chronic gastric disorders in pigs.
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REFERENCES
Banga-Mboko, H., Sulon, J., Closset, J., Remy, B., Youssao, De Sousa, N.M., El Amiri, B., Sangild, P.T., Maes, D. and Beckers, J.F., 2003. An improved radioimmunoassay for measurement of pepsinogen in porcine blood samples. The Veterinary Journal, 163, 288-295
Baumann, B. and Bilkei, G., 2002. Emergency-culling and mortality in growing/fattening pigs in a large Hungarian ‘farrow-to-finish’ production unit. Deutsche Tierärztliche Wochenschrift, 109, 26-33
Bunn, C.M., Hansky, J., Kelly, A. and Titchener, D.A., 1981. Observations on plasma gastrin and plasma pepsinogen in relation to weaning and gastric (pars oesophagea) ulceractions in pigs. Research in Veterinary Science, 30, 376-378
Castelino, J.B., Thomas, M., Herbert, I.V. and Lean, I.H., 1970. A survey of the prevalence of Hyostrongylus rubidus in breeding pigs slaughtered in North Wales. The Veterinary Record, 87, 256-257
Chartier, C., Mutesi, U. and Ndakala, N.O., 1990. Les helminthes du porc domestique en Ituri, Haut Zaïre. Annales de la Société Belge de Médécine Tropicale, 70, 213-225
Dangolla, A., Bjørn, H. and Nansen, P., 1994. A study on the transmission of Oesophagostomum dentatum and Hyostrongylus rubidus among outdoor reared pigs in Denmark. Acta Veterinaria Scandinavica, 35, 409-416
Deen, J., 1993. The problem of gastrophageal ulcers — a field description. In: D. Allen (ed.), Conference on the Evolution of the Swine Veterinary Profession, Minnesota, 1993, (Veterinary Continuing Education and Extension, University of Minnesota), 19-27
Doster, A.R., 2000. Porcine gastric ulcer. Veterinary Clinics of North America. Food Animal Practice, 16, 163-174
Elbers, A.R.W. and Dirkzwager, A., 1994. Changes in stomach mucosa in swine. Tijdschrift voor Diergeneeskunde, 119, 669-674
Elbers, A.R.W., Odinik, J.J.R. and Smeets, J.F.M., 1991. Change in haematological and clinicochemical profiles in blood of apparently healthy slaughter pigs collected at the farm and at slaughter in relation to the severity of pathological anatomical lesions. Veterinary Quarterly, 13, 1-9
Elbers, A.R.W., Counotte, G.H.M. and Tielen, M.J., 1992. Haematological and clinicomedical blood profiles in slaughter pigs. Veterinary Quarterly, 14, 57-62
Elbers, A.R.W., Hessing, M.J., Tielen, M.J. and Vos, J.H., 1995. Growth and oesophagogastric lesions in finishing pigs offered pelleted feed ad libitum. The Veterinary Record, 136, 588-590
Enight, K., Dey-Hazra, A. and Feder, H., 1972. Influence of Hyostrongylus infection on plasma pepsinogen content and electrolyte concentration of gastric juice in the pig. Zentalblatt für Veterinarmedizin, 19, 416-425
Ford, G.E., 1976. Blood pepsinogen estimations and production responses in trichostrongylid parasitism of ruminants. In: E.J.L. Soulsby (ed.), Pathophysiology of Parasitic Infections, (Academic Press, New York), 83-97
Gibbens, J.C., Gibbens, N.P. and Fielding, W.J., 1989. An abattoir survey of the prevalence of gastrointestinal helminths and Stephanurus dentatus in pigs in Belize. Tropical Animal Health and Production, 21, 197-204
Hessing, M.J., Geudeke, M.J., Scheepens, C.J., Tielen, M.J., Schouten, W.G. and Wiepkema, P.R., 1992. Mucosal lesions in the pars oesophagus in swine: prevalence and the effect of stress. Tijdschrift voor Diergeneeskunde, 117, 445-450
Knight, T., Greaves, S., Wilson, A., Hengels, K., Newel, D., Corlett, M., Webb, P., Forman, D. and Elder, J., 1995. Variability in serum pepsinogen levels in an asymptomatic population. European Journal of Gastroenterology and Hepatology, 7, 647-654
Leland, S.E., 1961. Blood and plasma volume, total serum protein, and electrophoretic studies in helminthic disease. Annals of the New York Academy of Sciences, 94, 163-182
Makinde, M.O. and Gous, T.A., 1998. Prevalence of gastro-oesophageal ulcers in grower-finisher pigs in the northern province of South Africa. Journal of the South African Veterinary Association, 69, 59-60
Martineau, G.P., 1997. Les maladies d'élevage des porcs, (Edition France Agricole, Paris), 480 p
Nappert, G., Vrins, A., Beauregard, M., Vermette, L. and Larivière, N., 1990. Radioimmunoassay of serum pepsinogen in relation to gastric (pars oesophagea) ulceration in swine herds. Canadian Journal of Veterinary Research, 54, 390-393
Pattison, H.D., Thomas, R.J. and Smith, W.C., 1980. A survey of gastrointestinal parasitism in pigs. The Veterinary Record, 107, 415-418
Permin, A., Yelifari, L., Bloch, P., Steenhard, N., Hansen, N.P. and Nansen, P., 1999. Parasites in crossbred pigs in the Upper East region of Ghana. Veterinary Parasitology, 87, 63-71
Salifu, D.A., Manga, T.B. and Ponytail, I.O., 1990. A survey of gastro-intestinal parasites in pigs of the Plateau and River states of Nigeria. Revue d'Élevage et de Médecine Vétérinaire des Pays Tropicaux, 43, 193-196
Samloff, I.M. and Liebman, W.M., 1974. Radioimmunoassay of group I pepsinogens in serum. Gastroenterology, 66, 494-502
Samloff, I.M., Leibman, W.M. and Pantch, N.M., 1975. Serum group I pepsinogens by radioimmunoassay in control subjects and patients with peptic ulcer. Gastroenterology, 69, 83-90
SAS, 1989. SAS User's Guide. Statistics, (Statistical Analysis System Institute Inc., Cary, NC)
Zamora, C.S., Kowalczyk, T., Hoekstra, W.G., Grummer, R.H. and Will, J.A., 1975. Plasma concentration of pepsinogen and corticosteroid in relation to gastric lesions in swine. American Journal of Veterinary Research, 36, 1327-1329
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Banga-Mboko, H., Tamboura, H., Maes, D. et al. Survey of Gastric Lesions and Blood Pepsinogen Levels in Pigs in Burkina Faso. Vet Res Commun 27, 595–602 (2003). https://doi.org/10.1023/A:1027368311808
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DOI: https://doi.org/10.1023/A:1027368311808