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A Possible Role of Slips in Cytochrome C Oxidase in the Antioxygen Defense System of the Cell

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Bioscience Reports

Abstract

Evidence is available showing that the coupling efficiency of the proton pump in cytochrome c oxidase of mitochondria can under certain conditions decrease significantly below the maximum attainable value. The view is developed that slips in the proton pump of cytochrome c oxidase represent an intrinsic switch mechanism which regulates the relative contribution of energy transfer and respiratory protection against oxygen toxicity by the oxidase.

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Authors and Affiliations

  1. Institute of Medical Biochemistry and Chemistry Medical Faculty, University of Bari, Piazza Giulio Cesare, Policlinico, 70124, Bari, Italy

    S. Papa, F. Guerrieri & N. Capitanio

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  1. S. Papa
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  2. F. Guerrieri
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  3. N. Capitanio
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Papa, S., Guerrieri, F. & Capitanio, N. A Possible Role of Slips in Cytochrome C Oxidase in the Antioxygen Defense System of the Cell. Biosci Rep 17, 23–31 (1997). https://doi.org/10.1023/A:1027331116866

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