Abstract
The experiments leading to the discovery of MHC-restricted T-cell killing of virus-infected cells are described. The implications of MHC- and HLA-restricted T-cell killing for the development of new vaccines and for the understanding of autoimmune disease are discussed.
Similar content being viewed by others
REFERENCES
Landsteiner, K. (1945) The specificity of serological reactions (Harvard University Press, Boston, Boston).
Klein, J. (1975) Biology of the mouse histocompatibility-2 complex (Springer Ltd.).
Dausset, J. (1958) Acta Haematol. (Basel.) 20:156-166.
Hotchin, J. (1962) Cold Spring Harvor Symp. Quant. Biol. 27:479-499.
Lehmann-Grube, F. (1971) Virol. Monogr. 10, 1-173.
Buchmeier, M. J., Welsh, R. M., Dutko, F. J. and Oldstone, M. B. A. (1980) Adv. Immunol. 30:275-331.
Brunner, K. T., Mauel, J., Cerottini, J. C. and Chapuis, B. (1968) Immunology 14:181-196.
Cerottini, J. C., Nordin, A. A. and Brunner, K. T. (1970) Nature 228:1308-1309.
Gardner, I., Bowern, N. A. and Blanden, R. V. (1974) Eur. J. Immunol. 4:63-67.
Marker, O. and Volkert, M. (1973) J. Exp. Med. 137:1511-1525.
Cole, G. A., Nathanson, N. and Prendergast, R. A. (1972) Nature 238:335-337.
Zinkernagel, R. M. and Doherty, P. C. (1973) J. Exp. Med. 138:1266-1269.
Oldstone, M. B., Dixon, F. J., Mitchell, G. F. and McDevitt, H. O. (1973) J. Exp. Med. 137:1201-1212.
Blanden, R. V. (1971) J. Exp. Med. 133:1074-1089.
Zinkernagel, R. M. and Doherty, P. C. (1974) Nature 248:701-702.
Mackaness, G. B. (1962) J. Exp. Med. 116:381-406.
Shearer, G. M. (1974) Eur. J. Immunol. 4:527-533.
Gorer, P. A. (1936). Brit. J. Exp. Pathol. 17:42-50.
Snell, G. D. (1948) J. Genet. 49:87-108.
Van Rood, J. J. and Van Leeuwen, A. (1963) J. Clin. Invest. 42:1382-1390.
Levine, B. B., Ojeda, A. P. and Benacerraf, B. (1963) Lapik, T.N. 118:953-957.
McDevitt, H. O. and Sela, M. (1965) J. Exp. Med. 122:517-531.
McDevitt, H. O. and Chintz, A. (1969) Science 163:1207-1210.
Lilly, F., Boyse, E. A. and Old, L. (1964) Lancet 2:1207-1209.
McDevitt, H. O., Deak, B. D., Shreffler, D. C., Klein, J., Stimpfling, J. H. and Snell, G. D. (1972) J. Exp. Med. 135:1259-1278.
Burnet, F. M. (1972) Nature 245:359-361.
Bodmer, W. F. (1972) Nature 237:139-145.
Benacerraf, B. and McDevitt, H. O. (1972) Science 175:273-279.
Amos, D. B., Bodmer, W. F., Ceppellini, R., Condliffe, P. G., Dausset, J. and Fahey, J. L. (1972) Fed. Proc. 31:1087-1104.
Jerne, N. K. (1971) Eur. J. Immunol. 1:1-9.
Lawrence, H. W. (1959) Physiol. Rev. 39:811-859.
Bailey, D. W., Snell, D. G. and Cherry, M. (1971) Proceedings of the Symposium on Immunogentics of the H-2 System. S. Karger AG, Basel, Switzerland.
Fathman, C. G. and Hengartner, H. (1978) Nature 272:617-618.
von Boehmer, H., Hengartner, H., Nabholz, M., Lernhardt, W., Schreier, M. H. and Haas, W. (1979) Eur. J. Immunol. 9:592-597 (1979).
Kappler, J. W., Skidmore, B., White, J. and Marrack, P. (1981) J. Exp. Med. 153:1198-1214.
Kappler, J., Kubo, R., Haskins, K. et al. (1983) Cell 35:295-302.
McIntyre, B. W. and Allison, J. P. (1983) Cell 34:739-746.
Hedrick, S. M., Cohen, D. I., Nielsen, E. A. and Davis, M. M. (1984) Nature 308:149-153.
Yanagi, Y., Yoshikai, Y., Leggett, K., Clark, S. P., Aleksaner, I. and Mak, T. W. (1984) Nature 308:145-149.
Leclerc, J. C., Gomard, E., Plata, F. and Levy, J. P. (1973) Int. J. Cancer 11:426-432.
Lavrin, D. H., Herbermann, R. B., Nunn, M. and Soares, N. (1973) J. Natl. Cancer Inst. 51:1497-1508.
Cole, G. A., Prendergast, R. A. and Henney, C. S. (1973a) Fed. Proc. 32:964.
Kindred, B. and Shreffler, D. C. (1972) J. Immunol. 109:940-943.
McCullagh, P. J. (1970) J. Exp. Med. 132:916-925.
Katz, D. H., Hamaoka, T. and Benacerraf, B. (1973) J. Exp. Med. 137:1405-1418.
Rosenthal, A. S. and Shevach, E. M. (1973) J. Exp. Med. 138:1194-1212.
Blanden, R. V., Doherty, P. C., Dunlop, M. B., Gardner, I. D., Zinkernagel, R. M. and David, C. S. (1975) Nature 254:269-270 (1975).
Kosczinowski, U. and Ertl, H. (1975) Nature 255:552-554.
Gordon, R. D., Simpson, E. and Samelson, L. E. (1975) J. Exp. Med. 142:1108-1120.
von Boehmer, H., Haas, W. and Jerne, N. K. (1978) Proc. Natl. Acad. Sci. U.S.A. 75:2439-2442.
Bevan, M. J. (1975) Nature 256:419-421.
McMichael, A. J., Ting, A., Zweerink, H. J. and Askonas, B. A. (1977) Nature 270:524-526.
Goulmy, E., Termijtelen, A., Bradley, B. A. and Van Rood, J. J. (1977) Nature 266:544-545.
Lafferty, K. J. and Cunningham, A. J. (1975) Aust. J. Exp. Biol. Med. Sci. 53:27-42.
Bretscher, P. and Cohn, M. (1970) Science 169:1042-1049.
Cohn, M. and Langman, R. E. (1990) Immunol. Rev. 115:11-147.
Zinkernagel, R. M. and Doherty, P. C. (1974) Nature 251:547-548.
Doherty, P. C. and Zinkernagel, R. M. (1975) J. Immunol. 114:30-33.
Gardner, I. D., Bowern, N. A. and Blanden, R. V. (1975) Eur. J. Immunol. 5:122-127.
Zinkernagel, R. M. (1974) Nature 251:230-233.
Doherty, P. C. and Zinkernagel, R. M. (1975) Lancet 1:1406-1409.
Babbitt, B. P., Allen, P. M., Matsueda, G., Haber, E. and Unanue, E. R. (1985) Nature 317:359-360.
Buus, C., Colon, S., Smith, C., Freed, J. H., Miles, C. and Grey, H. M. (1986) Proc. Natl. Acad. Sci. USA. 83:3968-3971.
Townsend, A. R. M., Rothbard, J., Gotch, F. M., Bahadur, G., Wraith, D. and McMichael, A. J. (1986) Cell 44:959-968.
Maryanski, J. L., Pala, P., Corradin, G., Jordan, B. R. and Cerottini, J. C. (1986) Nature 324:578-579.
Rotzschke, O., Falk, K., Deres, K., et al. (1990) Nature 348:252-254.
Lurquin, C., van Pel, A., Mariame, B., et al. (1989) Cell 58:293-303.
Bjorkman, P. J., Saper, M. A., Samraoui, B., Bennett, W. S., Strominger, J. L. and Wiley, D. C. (1987) Nature 329:506-511.
Bjorkman, P. L., Saper, M. A., Samraoui, B., Bennet, W. S., Strominger, J. L. and Wiley, D. C. (1987) Nature 329:512-518.
Garcia, K. C., Degano, M., Stanfield, R. L., et al. (1996) Science 274:209-219.
Garboczi, D. N., Ghosh, P., Utz, U., Fan, Q. R., Biddison, W. E. and Wiley, D. C. (1996) Nature 384:134-141.
Jorgensen, J. L., Esser, U., de St Groth, B. F., Reay, P. A. and Davis, M. M. (1992) Nature 355:224-230.
Sant'Angelo, D. B., Waterbury, G., Preston-Hurlburt, P., et al. (1996) Immunity 4:367-376.
Bevan, M. J. (1977) Nature 269:417-418.
Zinkernagel, R. M., Callahan, G. N., Klein, J. and Dennert, G. (1978) Nature 271:251-253.
Zinkernagel, R. M., Callahan, G. N., Althage, A., Cooper, S., Klein, P. A. and Klein, J. (1978) J. Exp. Med. 147:882-896 (1978).
Zinkernagel, R. M., Althage, A., Waterfield, E., et al. (1980) J. Exp. Med. 151:376-399.
Kisielow, P., Teh, H. S., Bluthmann, H. and von Boehmer, H. (1988) Nature 335:730-733.
Sha, W. C., Nelson, C. A., Newberry, R. D., Kranz, D. M., Russel, J. H. and Loh, D. Y. (1988) Nature 336:73-76.
Pircher, H., Mak, T. W., Lang, R., et al. (1989) EMBO J. 8:719-727.
Deres, K., Schild, H., Wiesmüller, K. H., Jung, G. and Rammensee, H. G. (1989) Nature 342:561-564.
Schulz, M., Zinkernagel, R. M. and Hengartner, H. (1991) Proc. Natl. Acad. Sci. U.S.A. 88:991-993.
Kast, W. M., Roux, L., Curren, J., et al. (1991) Proc. Natl. Acad. Sci. U.S.A. 88:2283-2287.
Widmann, C., Maryanski, J. L., Romero, P. and Corradin, G. (1991) J. Immunol. 147:3745-3751.
Clayton, J. P., Gammon, G. M., Ando, D. G., Kono, D. H., Hood, L. and Sercarz, E. E. (1989) J. Exp. Med. 169:1681-1691.
Gaur, A., Wiers, B., Lieu, A., Rothbard, J. and Fathman, C. G. (1992) Science 258:1491-1494.
Kyburz, D., Aichele, P., Speiser, D. E., Hengartner, H., Zinkernagel, R. M. and Pircher, H. (1993) Eur. J. Immunol. 23:1956-1962.
Aichele, P., Kyburz, D., Ohashi, P. S., et al. (1994) Proc. Natl. Acad. Sci. U.S.A. 91:444-448.
Oehen, St. Science, (1991A).
Aichele, P., Brduscha Riem, K., Zinkernagel, R. M., Hengartner, H. and Pircher, H. P. (1995) J. Exp. Med. 182:261-266.
Moskophidis, D., Lechner, F., Pircher, H. and Zinkernagel, R. M. (1993) Nature 362:758-761.
Zinkernagel, R. M. (1996) Science 271:173-178.
Pircher, H., Moskophidis, D., Rohrer, U., Bürki, K., Hengartner, H. and Zinkernagel, R. M. (1990) Nature 346:629-633.
Aebischer, T., Moskophidis, D., Rohrer, U. H., Zinkernagel, R. M. and Hengartner, H. (1991) Proc. Natl. Acad. Sci. U.S.A. 88:11047-11051.
Phillips, R. E., Rowland-Jones, S., Nixon, D. F., Gotch, F. M., Edwards, J. P., Ogunlesi, A. O. and McMichael, A. J. (1991) J. Nature 354:453-459.
Bertoletti, A., Sette, A., Chisari, F. V., Penna, A., Levrero, M. and De Carli, M. (1994) Nature 369:407-410.
Dausset, J. and Svejgaard, A. (1977) HLA and Disease.
Möller, E., Böhme, J., Valugerdi, M. A., Ridderstad, A. and Olerup, O. (1990) Imm. Rev. 118:5-19.
Zinkernagel, R. M. and Doherty, P. C. (1979) Adv. Immunol. 27:51-177.
Zinkernagel, R. M., Pfau, C. J., Hengartner, H. and Althage, A. (1985) Nature 316:814-817.
Pfau, C. J., Valenti, J. K., Pevear, D. C. and Hunt, D. (1982) J. Exp. Med. 156:79-89.
Leist, T. P., Althage, A., Haenseler, E., Hengartner, H. and Zinkernagel, R. M. (1989) J. Exp. Med. 170:269-277.
Moskophidis, D., Lechner, F., Hengartner, H. and Zinkernagel, R. M. (1994) J. Immunol. 152:4976-4983.
Moskophidis, D., Battegay, M., van den Broek, M. F., Laine, E., Hoffmann Rohrer, U. and Zinkernagel, R. M. (1995) J. Gen. Virol. 76:381-391.
Gray, D. and Leanderson, T. (1990) Curr. Top. Microbiol. Immunol. 159:1-17.
Jamieson, B. D. and Ahmed, R. (1989) J. Exp. Med. 169:1993-2005.
Beverley, P. C. (1990) Immunol. Today 11:203-205.
Zinkernagel, R. M., Bachmann, M. F., Kündig, T. M., Oehen, S., Pircher, H. and Hengartner, H. (1996) Annu. Rev. Immunol. 14:333-367.
Brambell, R. W. R. (1970) The Transmission of Immunity from Mother to Young, Amsterdam, North Holland.
Möller, G. (1983) Immunology of Feto-Maternal Relationship. Immunol. Rev. 75:5-230.
Bachmann, M. F., Odermatt, B., Hengartner, H. and Zinkernagel, R. M. (1996) J. Exp. Med. 183:2259-2269.
Steinhoff, U., Müller, U., Schertler, A., Hengartner, H., Aguet, M. and Zinkernagel, R. M. (1995) J. Virol. 69:2153-2158.
Gray, D. and Skarvall, H. (1988) Nature 336:70-73.
Bachmann, M. F., Kündig, T. M., Hengartner, H. and Zinkernagel, R. M. (1996) Proc. Natl. Acad. Sci. U.S.A. in press.
Kündig, T. M., Bachmann, M. F., Ohashi, P. S., Pürcher, H., Hengartner, H. and Zinkernagel, R. M. (1996) Immunol. Rev. 150:63-90.
Hou, S., Hyland, L., Ryan, K. W., Portner, A. and Doherty, P. C. (1994) Nature 369:652-654.
Lau, L. L., Jamieson, B. D., Somasundaram, T. and Ahmed, R. (1994) Nature 369:648-652.
Aichele, P., Hengartner, H., Zinkernagel, R. M. and Schulz, M. (1990) J. Exp. Med. 171:1815-1820.
Bachmann, M. F., Kündig, T. M., Odermatt, B., Hengartner, H. and Zinkernagel, R. M. (1994) J. Immunol. 153:3386-3397.
Bachmann, M. F., Fehr, T., Freer, G., Oxenius, A., Hengartner, H. and Zinkernagel, R. M. (in preparation).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Zinkernagel, R.M. Cellular Immune Recognition and the Biological Role of Major Transplantation Antigens. Biosci Rep 17, 91–111 (1997). https://doi.org/10.1023/A:1027303227595
Issue Date:
DOI: https://doi.org/10.1023/A:1027303227595