Skip to main content

Advertisement

Log in

Cellular Immune Recognition and the Biological Role of Major Transplantation Antigens

  • Published:
Bioscience Reports

Abstract

The experiments leading to the discovery of MHC-restricted T-cell killing of virus-infected cells are described. The implications of MHC- and HLA-restricted T-cell killing for the development of new vaccines and for the understanding of autoimmune disease are discussed.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

REFERENCES

  1. Landsteiner, K. (1945) The specificity of serological reactions (Harvard University Press, Boston, Boston).

    Google Scholar 

  2. Klein, J. (1975) Biology of the mouse histocompatibility-2 complex (Springer Ltd.).

  3. Dausset, J. (1958) Acta Haematol. (Basel.) 20:156-166.

    Google Scholar 

  4. Hotchin, J. (1962) Cold Spring Harvor Symp. Quant. Biol. 27:479-499.

    Google Scholar 

  5. Lehmann-Grube, F. (1971) Virol. Monogr. 10, 1-173.

    Google Scholar 

  6. Buchmeier, M. J., Welsh, R. M., Dutko, F. J. and Oldstone, M. B. A. (1980) Adv. Immunol. 30:275-331.

    Google Scholar 

  7. Brunner, K. T., Mauel, J., Cerottini, J. C. and Chapuis, B. (1968) Immunology 14:181-196.

    Google Scholar 

  8. Cerottini, J. C., Nordin, A. A. and Brunner, K. T. (1970) Nature 228:1308-1309.

    Google Scholar 

  9. Gardner, I., Bowern, N. A. and Blanden, R. V. (1974) Eur. J. Immunol. 4:63-67.

    Google Scholar 

  10. Marker, O. and Volkert, M. (1973) J. Exp. Med. 137:1511-1525.

    Google Scholar 

  11. Cole, G. A., Nathanson, N. and Prendergast, R. A. (1972) Nature 238:335-337.

    Google Scholar 

  12. Zinkernagel, R. M. and Doherty, P. C. (1973) J. Exp. Med. 138:1266-1269.

    Google Scholar 

  13. Oldstone, M. B., Dixon, F. J., Mitchell, G. F. and McDevitt, H. O. (1973) J. Exp. Med. 137:1201-1212.

    Google Scholar 

  14. Blanden, R. V. (1971) J. Exp. Med. 133:1074-1089.

    Google Scholar 

  15. Zinkernagel, R. M. and Doherty, P. C. (1974) Nature 248:701-702.

    Google Scholar 

  16. Mackaness, G. B. (1962) J. Exp. Med. 116:381-406.

    Google Scholar 

  17. Shearer, G. M. (1974) Eur. J. Immunol. 4:527-533.

    Google Scholar 

  18. Gorer, P. A. (1936). Brit. J. Exp. Pathol. 17:42-50.

    Google Scholar 

  19. Snell, G. D. (1948) J. Genet. 49:87-108.

    Google Scholar 

  20. Van Rood, J. J. and Van Leeuwen, A. (1963) J. Clin. Invest. 42:1382-1390.

    Google Scholar 

  21. Levine, B. B., Ojeda, A. P. and Benacerraf, B. (1963) Lapik, T.N. 118:953-957.

    Google Scholar 

  22. McDevitt, H. O. and Sela, M. (1965) J. Exp. Med. 122:517-531.

    Google Scholar 

  23. McDevitt, H. O. and Chintz, A. (1969) Science 163:1207-1210.

    Google Scholar 

  24. Lilly, F., Boyse, E. A. and Old, L. (1964) Lancet 2:1207-1209.

    Google Scholar 

  25. McDevitt, H. O., Deak, B. D., Shreffler, D. C., Klein, J., Stimpfling, J. H. and Snell, G. D. (1972) J. Exp. Med. 135:1259-1278.

    Google Scholar 

  26. Burnet, F. M. (1972) Nature 245:359-361.

    Google Scholar 

  27. Bodmer, W. F. (1972) Nature 237:139-145.

    Google Scholar 

  28. Benacerraf, B. and McDevitt, H. O. (1972) Science 175:273-279.

    Google Scholar 

  29. Amos, D. B., Bodmer, W. F., Ceppellini, R., Condliffe, P. G., Dausset, J. and Fahey, J. L. (1972) Fed. Proc. 31:1087-1104.

    Google Scholar 

  30. Jerne, N. K. (1971) Eur. J. Immunol. 1:1-9.

    Google Scholar 

  31. Lawrence, H. W. (1959) Physiol. Rev. 39:811-859.

    Google Scholar 

  32. Bailey, D. W., Snell, D. G. and Cherry, M. (1971) Proceedings of the Symposium on Immunogentics of the H-2 System. S. Karger AG, Basel, Switzerland.

    Google Scholar 

  33. Fathman, C. G. and Hengartner, H. (1978) Nature 272:617-618.

    Google Scholar 

  34. von Boehmer, H., Hengartner, H., Nabholz, M., Lernhardt, W., Schreier, M. H. and Haas, W. (1979) Eur. J. Immunol. 9:592-597 (1979).

    Google Scholar 

  35. Kappler, J. W., Skidmore, B., White, J. and Marrack, P. (1981) J. Exp. Med. 153:1198-1214.

    Google Scholar 

  36. Kappler, J., Kubo, R., Haskins, K. et al. (1983) Cell 35:295-302.

    Google Scholar 

  37. McIntyre, B. W. and Allison, J. P. (1983) Cell 34:739-746.

    Google Scholar 

  38. Hedrick, S. M., Cohen, D. I., Nielsen, E. A. and Davis, M. M. (1984) Nature 308:149-153.

    Google Scholar 

  39. Yanagi, Y., Yoshikai, Y., Leggett, K., Clark, S. P., Aleksaner, I. and Mak, T. W. (1984) Nature 308:145-149.

    Google Scholar 

  40. Leclerc, J. C., Gomard, E., Plata, F. and Levy, J. P. (1973) Int. J. Cancer 11:426-432.

    Google Scholar 

  41. Lavrin, D. H., Herbermann, R. B., Nunn, M. and Soares, N. (1973) J. Natl. Cancer Inst. 51:1497-1508.

    Google Scholar 

  42. Cole, G. A., Prendergast, R. A. and Henney, C. S. (1973a) Fed. Proc. 32:964.

    Google Scholar 

  43. Kindred, B. and Shreffler, D. C. (1972) J. Immunol. 109:940-943.

    Google Scholar 

  44. McCullagh, P. J. (1970) J. Exp. Med. 132:916-925.

    Google Scholar 

  45. Katz, D. H., Hamaoka, T. and Benacerraf, B. (1973) J. Exp. Med. 137:1405-1418.

    Google Scholar 

  46. Rosenthal, A. S. and Shevach, E. M. (1973) J. Exp. Med. 138:1194-1212.

    Google Scholar 

  47. Blanden, R. V., Doherty, P. C., Dunlop, M. B., Gardner, I. D., Zinkernagel, R. M. and David, C. S. (1975) Nature 254:269-270 (1975).

    Google Scholar 

  48. Kosczinowski, U. and Ertl, H. (1975) Nature 255:552-554.

    Google Scholar 

  49. Gordon, R. D., Simpson, E. and Samelson, L. E. (1975) J. Exp. Med. 142:1108-1120.

    Google Scholar 

  50. von Boehmer, H., Haas, W. and Jerne, N. K. (1978) Proc. Natl. Acad. Sci. U.S.A. 75:2439-2442.

    Google Scholar 

  51. Bevan, M. J. (1975) Nature 256:419-421.

    Google Scholar 

  52. McMichael, A. J., Ting, A., Zweerink, H. J. and Askonas, B. A. (1977) Nature 270:524-526.

    Google Scholar 

  53. Goulmy, E., Termijtelen, A., Bradley, B. A. and Van Rood, J. J. (1977) Nature 266:544-545.

    Google Scholar 

  54. Lafferty, K. J. and Cunningham, A. J. (1975) Aust. J. Exp. Biol. Med. Sci. 53:27-42.

    Google Scholar 

  55. Bretscher, P. and Cohn, M. (1970) Science 169:1042-1049.

    Google Scholar 

  56. Cohn, M. and Langman, R. E. (1990) Immunol. Rev. 115:11-147.

    Google Scholar 

  57. Zinkernagel, R. M. and Doherty, P. C. (1974) Nature 251:547-548.

    Google Scholar 

  58. Doherty, P. C. and Zinkernagel, R. M. (1975) J. Immunol. 114:30-33.

    Google Scholar 

  59. Gardner, I. D., Bowern, N. A. and Blanden, R. V. (1975) Eur. J. Immunol. 5:122-127.

    Google Scholar 

  60. Zinkernagel, R. M. (1974) Nature 251:230-233.

    Google Scholar 

  61. Doherty, P. C. and Zinkernagel, R. M. (1975) Lancet 1:1406-1409.

    Google Scholar 

  62. Babbitt, B. P., Allen, P. M., Matsueda, G., Haber, E. and Unanue, E. R. (1985) Nature 317:359-360.

    Google Scholar 

  63. Buus, C., Colon, S., Smith, C., Freed, J. H., Miles, C. and Grey, H. M. (1986) Proc. Natl. Acad. Sci. USA. 83:3968-3971.

    Google Scholar 

  64. Townsend, A. R. M., Rothbard, J., Gotch, F. M., Bahadur, G., Wraith, D. and McMichael, A. J. (1986) Cell 44:959-968.

    Google Scholar 

  65. Maryanski, J. L., Pala, P., Corradin, G., Jordan, B. R. and Cerottini, J. C. (1986) Nature 324:578-579.

    Google Scholar 

  66. Rotzschke, O., Falk, K., Deres, K., et al. (1990) Nature 348:252-254.

    Google Scholar 

  67. Lurquin, C., van Pel, A., Mariame, B., et al. (1989) Cell 58:293-303.

    Google Scholar 

  68. Bjorkman, P. J., Saper, M. A., Samraoui, B., Bennett, W. S., Strominger, J. L. and Wiley, D. C. (1987) Nature 329:506-511.

    Google Scholar 

  69. Bjorkman, P. L., Saper, M. A., Samraoui, B., Bennet, W. S., Strominger, J. L. and Wiley, D. C. (1987) Nature 329:512-518.

    Google Scholar 

  70. Garcia, K. C., Degano, M., Stanfield, R. L., et al. (1996) Science 274:209-219.

    Google Scholar 

  71. Garboczi, D. N., Ghosh, P., Utz, U., Fan, Q. R., Biddison, W. E. and Wiley, D. C. (1996) Nature 384:134-141.

    Google Scholar 

  72. Jorgensen, J. L., Esser, U., de St Groth, B. F., Reay, P. A. and Davis, M. M. (1992) Nature 355:224-230.

    Google Scholar 

  73. Sant'Angelo, D. B., Waterbury, G., Preston-Hurlburt, P., et al. (1996) Immunity 4:367-376.

    Google Scholar 

  74. Bevan, M. J. (1977) Nature 269:417-418.

    Google Scholar 

  75. Zinkernagel, R. M., Callahan, G. N., Klein, J. and Dennert, G. (1978) Nature 271:251-253.

    Google Scholar 

  76. Zinkernagel, R. M., Callahan, G. N., Althage, A., Cooper, S., Klein, P. A. and Klein, J. (1978) J. Exp. Med. 147:882-896 (1978).

    Google Scholar 

  77. Zinkernagel, R. M., Althage, A., Waterfield, E., et al. (1980) J. Exp. Med. 151:376-399.

    Google Scholar 

  78. Kisielow, P., Teh, H. S., Bluthmann, H. and von Boehmer, H. (1988) Nature 335:730-733.

    Google Scholar 

  79. Sha, W. C., Nelson, C. A., Newberry, R. D., Kranz, D. M., Russel, J. H. and Loh, D. Y. (1988) Nature 336:73-76.

    Google Scholar 

  80. Pircher, H., Mak, T. W., Lang, R., et al. (1989) EMBO J. 8:719-727.

    Google Scholar 

  81. Deres, K., Schild, H., Wiesmüller, K. H., Jung, G. and Rammensee, H. G. (1989) Nature 342:561-564.

    Google Scholar 

  82. Schulz, M., Zinkernagel, R. M. and Hengartner, H. (1991) Proc. Natl. Acad. Sci. U.S.A. 88:991-993.

    Google Scholar 

  83. Kast, W. M., Roux, L., Curren, J., et al. (1991) Proc. Natl. Acad. Sci. U.S.A. 88:2283-2287.

    Google Scholar 

  84. Widmann, C., Maryanski, J. L., Romero, P. and Corradin, G. (1991) J. Immunol. 147:3745-3751.

    Google Scholar 

  85. Clayton, J. P., Gammon, G. M., Ando, D. G., Kono, D. H., Hood, L. and Sercarz, E. E. (1989) J. Exp. Med. 169:1681-1691.

    Google Scholar 

  86. Gaur, A., Wiers, B., Lieu, A., Rothbard, J. and Fathman, C. G. (1992) Science 258:1491-1494.

    Google Scholar 

  87. Kyburz, D., Aichele, P., Speiser, D. E., Hengartner, H., Zinkernagel, R. M. and Pircher, H. (1993) Eur. J. Immunol. 23:1956-1962.

    Google Scholar 

  88. Aichele, P., Kyburz, D., Ohashi, P. S., et al. (1994) Proc. Natl. Acad. Sci. U.S.A. 91:444-448.

    Google Scholar 

  89. Oehen, St. Science, (1991A).

  90. Aichele, P., Brduscha Riem, K., Zinkernagel, R. M., Hengartner, H. and Pircher, H. P. (1995) J. Exp. Med. 182:261-266.

    Google Scholar 

  91. Moskophidis, D., Lechner, F., Pircher, H. and Zinkernagel, R. M. (1993) Nature 362:758-761.

    Google Scholar 

  92. Zinkernagel, R. M. (1996) Science 271:173-178.

    Google Scholar 

  93. Pircher, H., Moskophidis, D., Rohrer, U., Bürki, K., Hengartner, H. and Zinkernagel, R. M. (1990) Nature 346:629-633.

    Google Scholar 

  94. Aebischer, T., Moskophidis, D., Rohrer, U. H., Zinkernagel, R. M. and Hengartner, H. (1991) Proc. Natl. Acad. Sci. U.S.A. 88:11047-11051.

    Google Scholar 

  95. Phillips, R. E., Rowland-Jones, S., Nixon, D. F., Gotch, F. M., Edwards, J. P., Ogunlesi, A. O. and McMichael, A. J. (1991) J. Nature 354:453-459.

    Google Scholar 

  96. Bertoletti, A., Sette, A., Chisari, F. V., Penna, A., Levrero, M. and De Carli, M. (1994) Nature 369:407-410.

    Google Scholar 

  97. Dausset, J. and Svejgaard, A. (1977) HLA and Disease.

  98. Möller, E., Böhme, J., Valugerdi, M. A., Ridderstad, A. and Olerup, O. (1990) Imm. Rev. 118:5-19.

    Google Scholar 

  99. Zinkernagel, R. M. and Doherty, P. C. (1979) Adv. Immunol. 27:51-177.

    Google Scholar 

  100. Zinkernagel, R. M., Pfau, C. J., Hengartner, H. and Althage, A. (1985) Nature 316:814-817.

    Google Scholar 

  101. Pfau, C. J., Valenti, J. K., Pevear, D. C. and Hunt, D. (1982) J. Exp. Med. 156:79-89.

    Google Scholar 

  102. Leist, T. P., Althage, A., Haenseler, E., Hengartner, H. and Zinkernagel, R. M. (1989) J. Exp. Med. 170:269-277.

    Google Scholar 

  103. Moskophidis, D., Lechner, F., Hengartner, H. and Zinkernagel, R. M. (1994) J. Immunol. 152:4976-4983.

    Google Scholar 

  104. Moskophidis, D., Battegay, M., van den Broek, M. F., Laine, E., Hoffmann Rohrer, U. and Zinkernagel, R. M. (1995) J. Gen. Virol. 76:381-391.

    Google Scholar 

  105. Gray, D. and Leanderson, T. (1990) Curr. Top. Microbiol. Immunol. 159:1-17.

    Google Scholar 

  106. Jamieson, B. D. and Ahmed, R. (1989) J. Exp. Med. 169:1993-2005.

    Google Scholar 

  107. Beverley, P. C. (1990) Immunol. Today 11:203-205.

    Google Scholar 

  108. Zinkernagel, R. M., Bachmann, M. F., Kündig, T. M., Oehen, S., Pircher, H. and Hengartner, H. (1996) Annu. Rev. Immunol. 14:333-367.

    Google Scholar 

  109. Brambell, R. W. R. (1970) The Transmission of Immunity from Mother to Young, Amsterdam, North Holland.

  110. Möller, G. (1983) Immunology of Feto-Maternal Relationship. Immunol. Rev. 75:5-230.

    Google Scholar 

  111. Bachmann, M. F., Odermatt, B., Hengartner, H. and Zinkernagel, R. M. (1996) J. Exp. Med. 183:2259-2269.

    Google Scholar 

  112. Steinhoff, U., Müller, U., Schertler, A., Hengartner, H., Aguet, M. and Zinkernagel, R. M. (1995) J. Virol. 69:2153-2158.

    Google Scholar 

  113. Gray, D. and Skarvall, H. (1988) Nature 336:70-73.

    Google Scholar 

  114. Bachmann, M. F., Kündig, T. M., Hengartner, H. and Zinkernagel, R. M. (1996) Proc. Natl. Acad. Sci. U.S.A. in press.

  115. Kündig, T. M., Bachmann, M. F., Ohashi, P. S., Pürcher, H., Hengartner, H. and Zinkernagel, R. M. (1996) Immunol. Rev. 150:63-90.

    Google Scholar 

  116. Hou, S., Hyland, L., Ryan, K. W., Portner, A. and Doherty, P. C. (1994) Nature 369:652-654.

    Google Scholar 

  117. Lau, L. L., Jamieson, B. D., Somasundaram, T. and Ahmed, R. (1994) Nature 369:648-652.

    Google Scholar 

  118. Aichele, P., Hengartner, H., Zinkernagel, R. M. and Schulz, M. (1990) J. Exp. Med. 171:1815-1820.

    Google Scholar 

  119. Bachmann, M. F., Kündig, T. M., Odermatt, B., Hengartner, H. and Zinkernagel, R. M. (1994) J. Immunol. 153:3386-3397.

    Google Scholar 

  120. Bachmann, M. F., Fehr, T., Freer, G., Oxenius, A., Hengartner, H. and Zinkernagel, R. M. (in preparation).

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Zinkernagel, R.M. Cellular Immune Recognition and the Biological Role of Major Transplantation Antigens. Biosci Rep 17, 91–111 (1997). https://doi.org/10.1023/A:1027303227595

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1027303227595

Navigation