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Association study of proposed candidate genes/regions in a population of Spanish asthmatics

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Abstract

A number of genes/regions have recently been reported to be linked to asthma or its related phenotypes (i.e. atopy and bronchial hyperresponsiveness), by genetic linkage and allele-sharing methods. We have performed a case–control study comparing the allelic distribution of nine microsatellite markers and two genetic variants in a group of patients attended at emergency room departments because of an acute attack of asthma with respect to an external healthy population of controls. A total of 146 asthmatic subjects and 50 population controls from Barcelona, Spain, were genotyped for nine microsatellite markers from some asthma/atopy candidate genes/regions: the β-subunit of the high-affinity IgE receptor (FcεRI-β) located on chromosome 11; the 5q31–32 candidate region; the T-cell receptor genes, TCR-α on chromosome 14 and TCR-β on chromosome 7. Two genetic variants of the β-subunit of the high-affinity IgE receptor (FcεRI-β) gene were also analyzed. None of the asthmatic or control individuals carried the Ile181Leu variant. There were no significant differences between asthmatic and control subjects neither for the polymorphic markers nor for the other variant of the β-subunit of the high-affinity IgE receptor (FcεRI-β) gene. No association could be observed in this sample of Spanish asthmatics with the genes/regions studied.

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Authors and Affiliations

  1. Departament d'Epidemiologia i Salut Pública, Institut Municipal d'Investigació Mèdica, Barcelona, Spain

    J.B. Soriano, J.M. Antó & J. Sunyer

  2. Department of Epidemiology, Johns Hopkins School of Hygiene and Public Health, Baltimore, USA

    J.B. Soriano & T.H. Beaty

  3. Centre de Genètica Mèdica i Molecular – IRO, Hospital Duran i Reynals, Barcelona, Spain

    R. de Cid, X. Estivill, D. Otero & C. Lázaro

  4. Servei de Pneumologia, Departament de Medicina, Hospital Clínic, Barcelona, Spain

    J. Roca, R. Rodríguez-Roisín & G. Ercilla

  5. Departament de Pneumologia i Bioquímica, Hospital Universitari Vall d'Hebron, Barcelona, Spain

    F. Morell & M.J. Rodrigo

Authors
  1. J.B. Soriano
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  2. R. de Cid
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  3. X. Estivill
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  4. J.M. Antó
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  5. J. Sunyer
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  6. D. Otero
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  7. J. Roca
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  8. R. Rodríguez-Roisín
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  9. F. Morell
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  10. M.J. Rodrigo
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  11. G. Ercilla
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  12. T.H. Beaty
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  13. C. Lázaro
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Soriano, J., de Cid, R., Estivill, X. et al. Association study of proposed candidate genes/regions in a population of Spanish asthmatics. Eur J Epidemiol 16, 745–750 (2000). https://doi.org/10.1023/A:1026758319621

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