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Structure and Function of tmRNA (10Sa RNA)

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Abstract

Modern data on the structure and function of transport/messenger (tm) RNA are reviewed. This stable RNA is involved in releasing ribosomes that are unable to complete protein synthesis on mRNA lacking the stop codon. The resulting abnormal proteins are rapidly degraded by specific proteases, which recognize a signal peptide encoded by the template region of tmRNA. The discovery of trans-translation has caused a particular interest in structural and functional studies of tmRNA.

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Authors and Affiliations

  1. Chemical Faculty, Moscow State University, Moscow, 119899, Russia

    M. E. Zvereva, O. V. Shpanchenko, O. A. Dontsova & A. A. Bogdanov

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  1. M. E. Zvereva
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  2. O. V. Shpanchenko
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  3. O. A. Dontsova
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  4. A. A. Bogdanov
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Zvereva, M.E., Shpanchenko, O.V., Dontsova, O.A. et al. Structure and Function of tmRNA (10Sa RNA). Molecular Biology 34, 927–933 (2000). https://doi.org/10.1023/A:1026692229336

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