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Remodeling of Vascular Wall in Crohn's Disease

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Abstract

To clarify the changes in vascular resistance inCrohn's disease, we studied changes in the thickness ofarterial media histometrically. The resected specimensof mesenterium and intestine from 18 patients with Crohn's disease were used. Each intestinallesion was classified into three grades: noinflammation, exudative change, and fibrosing change. Inthe ileum, significant atrophy in the media of thesubmucosal peripheral arteries was noted during exudativeand fibrosing changes, while in the submucosal largervessels or in the mesenterium, the thickness of thearterial media did not change. In the colon, atrophy in the media of the submucosal arteries wasnoted in all stages except in the larger vessel duringexudative change, while no significant changes werenoted in the mesenterium. In conclusion, it is suggested that circulatory disturbance occurs even in theearly stage in Crohn's disease, and there seems to beincreased vascular resistance in the area between thedeep submucosal and the distal mesentericarteries.

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REFERENCES

  1. Ward M: The pathogenesis of Crohn's disease. Lancet 2:903-905, 1977

    Google Scholar 

  2. Knutson H, Lunderquist A, Lunderquist A: Vascular changes in Crohn's disease. Am J Roentgenol 103:380-385, 1968

    Google Scholar 

  3. Fazio VW, Tjandra JJ, Lavery IC, Church JM, Milsom JW, Oakley JR: Long-term follow-up of strictureplasty in Crohn's disease. Dis Colon Rectum 36:355-361, 1993

    Google Scholar 

  4. Wakefield AJ, Sawyerr AM, Dhillon AP, Pittilo RM, Rowles PM, Lewis AA, Pounder RE: Pathogenesis of Crohn's disease: Multifocal gastrointestinal infarction. Lancet 2:1057-1062, 1989

    Google Scholar 

  5. Bacaner MB: Quantitative measurement of regional colon blood flow in the normal and pathological human bowel. Gastroenterology 51:764-777, 1966

    Google Scholar 

  6. Hultén L, Lindhagen J, Lundgren O, Fasth S, Ahrén C: Regional intestinal blood flow in ulcerative colitis and Crohn's disease. Gastroenterology 72:388-396, 1977

    Google Scholar 

  7. Logan RFA, Katschinski B, Somerville KW, Pearson JCG, Langman MJS: Smoking and inflammatory bowel disease. Gastroenterology 90:1525, 1986

    Google Scholar 

  8. Sutherland LR, Ramcharan S, Bryant H, Fick G: Effect of cigarette smoking on recurrence of Crohn's disease. Gastroenterology 98:1123-1128, 1990

    Google Scholar 

  9. Srivastava ED, Russell MA, Feyerabend C, Rhodes J: Effect of ulcerative colitis and smoking on rectal blood flow. Gut 31:1021-1024, 1990

    Google Scholar 

  10. Wakefield AJ, Sawyerr AM, Hudson M, Dhillon AP, Pounder RE: Smoking, the oral contraceptive pill, and Crohn's disease. Dig Dis Sci 36:1147-1150, 1991

    Google Scholar 

  11. Suwa N, Takahashi T: Morphological and Morphometrical Analysis of Circulation in Hypertension and Ischemic Kidney. Munich, Urban and Schwarzenberg, 1971

  12. Warren S, Sommers S: Pathology of regional ileitis and ulcerative colitis. JAMA 154:189-193, 1954

    Google Scholar 

  13. Reiffersheid M, Wolfram E: Resektion oder Umgehungsan astomose bei der Enteritis regionalis? Chirurg 33:164-172, 1962

    Google Scholar 

  14. Brahme F, Lindstörm C: A comparative radiographic and pathological study of intestinal vasoarchitecture in Crohn's disease and in ulcerative colitis. Gut 11:928-940, 1970

    Google Scholar 

  15. Lunderquist A, Knutsson H: Angiography in Crohn's disease of the small bowel and colon. Am J Roentgenol 101:338-344, 1967

    Google Scholar 

  16. Brahme F: Mesenteric angiography in regional enterocolitis. Radiology 87:1037-1042, 1966

    Google Scholar 

  17. Carr ND, Pullan BR, Schofield PF: Microvascular studies in non-specific inflammatory bowel disease. Gut 27:542-549, 1986

    Google Scholar 

  18. Angerson WJ, Allison MC, Baxter JN, Russell RI: Neoterminal ileal blood flow after ileocolonic resection for Crohn's disease. Gut 34:1531-1534, 1993

    Google Scholar 

  19. Gibbons GH, Dzau VJ: The emerging concept of vascular remodeling. N Engl J Med 330:1431-1438, 1994

    Google Scholar 

  20. Wakefield AJ, Sankey EA, Dhillon AP, Sawyerr AM, More L, Sim R, Pittilo RM, Rowles PM, Hudson M, Lewis AAM, Pounder RE: Granulomatous vasculitis in Crohn's disease. Gastroenterology 100:1279-1287, 1991

    Google Scholar 

  21. Dvorak AM, Monahan RA, Osage JE, Dickersin GR: Crohn's disease: Transmission electron microscopic studies. II. Immunologic inflammatory response. Alterations of mast cells, basophils, eosinophils and microvasculature. Hum Pathol 11:606-619, 1980

    Google Scholar 

  22. Kuramoto S, Oohara T, Ihara O, Shimazu R, Kondo Y: Granulomas of the gut in Crohn's disease. A step sectioning study. Dis Colon Rectum 30:6-11, 1987

    Google Scholar 

  23. Hadfield G. The primary histological lesion of regional ileitis. Lancet 2:773-775, 1939

    Google Scholar 

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Authors
  1. Yuji Funayama
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  2. Iwao Sasaki
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  3. Hiroo Naito
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  4. Kohei Fukushima
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  5. Seiki Matsuno
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  6. Takayuki Masuda
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Funayama, Y., Sasaki, I., Naito, H. et al. Remodeling of Vascular Wall in Crohn's Disease. Dig Dis Sci 44, 2319–2323 (1999). https://doi.org/10.1023/A:1026677325411

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  • DOI: https://doi.org/10.1023/A:1026677325411

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