Abstract
A complex compound of high-molecular heparin and glutamic acid has been synthesized. This compound has anticoagulant, fibrinolytic, and antithrombotic properties in vitro. Single intravenous or chronic peroral introduction of the complex in normal animals imitates the activation of anticoagulation system. When the anticoagulation system in depressed, the complex restores or even activates the anticoagulant–fibrinolytic background of the serum it. The obtained data are discussed in physiological terms.
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REFERENCES
Abildgaard, U., Heparin (Low Molecular Weight Heparin and Tissue Factor Pathway Inhibitor), Haemostasis, 1993, vol. 23, suppl. 1, p. 103.
Andreenko, G.V. Assays for Fibrinolytic Activity of the Blood, Lab. Delo, 1962, no. 5, p. 3.
Ashmarin, I.P.,Lyapina, L.A., andPastorova, V.E., Modulation of Hemostatic Responses in vitroand in vivoby Representatives of Control Peptides Families, Vestnik Ross. Akad. Med. Nauk, 1996, no. 6, p. 50.
Astrup, T. andMellertz, S., The Fibrin Plate Method for Estimating Fibrinolytic Activity, Arch.Biochem. Biophys., 1952, vol. 40, p. 346.
Born, G.V.R., Aggregation of Blood Platelets by Adenosindiphosphate and Its Reversal, Nature, 1962, vol. 194, p. 927.
Buluk, K., Januszko, T., and Olbramski, Y., Conversion of Fibrin to Desmofibrin, Nature, 1961, vol. 191, p. 1093.
Doutremepuich, Ch.,Lalanne, M.C.,Doutremepuich, F., andPuyal, Ch., Low Molecular Weight Heparins in Clinical Practice, Doutremepuich, Ch., Ed., Marcel: Dekker, 1992, p. 85.
Fareed, J., An Update on Anticoagulant and Antithrombotic Drugs, Advances Anticoagulant, Antithrombotic and Thrombolytic Therapeutics, 1996, p. 3.
Koh, T.J. andBarucha, K.R., Stable Orally Active Heparinoid Complexes, US Patent 3 577 534, 1971.
Kudrjashov, B.A.,Lyapina, L.A., Non-Enzymatic Fibrinolysis and Its Role in the Organism, Thrombosis Thrombolysis, N.Y.: Consultant burea, 1986, p. 33.
Kudryashov, B.A.,Lyapina, L.A., andBaskova, I.P., Improvement of the Method of Determination of Nonenzymatic Fibrinolytic Activity of Blood Plasma and some of its Components, Vestnik MGU. Biolog. Pochvoved., 1974, no. 5, pp. 41-45.
Kudryashov, B.A.,Lyapina, L.A., andKondashevskaya M.V., Fibrinolytic and Thrombolytic Properties of Low-molecular Heparin-Nicotinamide Complex, Fiziologiya cheloveka, 1993,. vol. 19, no. 5, p. 156.
Mansfeld, V. andHladovec, J., Studien uber Reactionen des Kristallisierten Trypsins. II. Beziehung Zwischen der Activitat des Heparins und Trypsins, Collection of Czechoslovak Chemical Communication, 1957, vol. 21, no. 5, p. 1209.
Nakamura, S.,Takeo, K.,Tanaka, K., andUeta, T., Kreuzungsverfahren bei Papierelectrophoresis, Hoppe-Seyler' Z. Physiol. Chem., 1960, vol. 318, no. 1, p. 115.
Vidal, Spravochnik. Lekarstvennye preparaty v Rossii(Catalogue. Pharmaceuticals in Russia), Moscow: OVPEE-Astra-FarmServis, 2000, p. E-152.
Young, E.,Cosmi, B.,Weitz. J, andHirsh, J., Comparison of the Non-Specific Binding of Unfractionated Heparin and Low Molecular Weight Heparin (Enoxiparin) to Plasma Proteins, Thromb. Aemost. Stuttgart, 1993, vol. 70, no. 4, p. 625.
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Lyapina, L.A., Ziadetdinova, G.A. Complex Compound of Heparin and Glutamic Acid: Synthesis and Effect on Hemostatic Indices in vitro and in vivo. Biology Bulletin 28, 71–74 (2001). https://doi.org/10.1023/A:1026662822183
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DOI: https://doi.org/10.1023/A:1026662822183