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Iron Chelator Deferoxamine Reduces Preneoplastic Lesions in Liver Induced by Choline-Deficient L-Amino Acid-Defined Diet in Rats

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Abstract

The aim of this study was to investigate wheThe ran iron chelator, deferoxamine (DFO) can prevent lipidperoxidation, resulting in reduced liver injury as wellas reducing preneoplastic lesions induced by a choline-deficient L-amino acid-defined(CDAA) diet. CDAA diet administration resulted in anincreased serum ALT level (367 ± 58) after twoweeks, but simultaneous DFO treatment for two weeksreduced this elevation of ALT as well asmalondialdehyde (MDA) production in the liver. Feedingrats a CDAA diet for 12 weeks led to the development ofsevere liver fibrosis and preneoplastic lesions detectedas enzymealtered lesions. DFO treatment preventedthe expression of activated stellate cells, resulting inThe reduction of liver fibrosis as well as reducing thedevelopment of preneoplastic lesions. These results indicate that iron chelation can reducethe development of preneoplastic lesions in a CDAA dietmodel.

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Authors
  1. Isao Sakaida
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  2. Koji Hironaka
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  3. Koichi Uchida
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  4. Kiwamu Okita
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Sakaida, I., Hironaka, K., Uchida, K. et al. Iron Chelator Deferoxamine Reduces Preneoplastic Lesions in Liver Induced by Choline-Deficient L-Amino Acid-Defined Diet in Rats. Dig Dis Sci 44, 560–569 (1999). https://doi.org/10.1023/A:1026661508553

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