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A Biological Model of Accelerated Senescence. 1. The Rate of the Spontaneous Mutation Process in Spermatogenesis of Senescence-Accelerated Mice

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Abstract

We studied the dynamics of age-related cytogenetic changes in the developing male germ cells of mice prone to accelerated senescence (strain SAMP1) and mice resistant to accelerated senescence (strain SAMP1) by counting the spermatogonial and meiotic micronuclei and testing the defects of the spermatozoon head shape. In these animals, the accumulation of germinative mutations has a nonlinear pattern. During the entire ontogenesis of SAMP1 mice, the frequency of circular spermatids with micronuclei corresponded to the level observed upon induced mutagenesis.

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REFERENCES

  • Allen, J.W. andGwaltney, C.W., Investigation of Possible Age Effects on Meiotic Chromosomal Recombination and Segregation in Armenian Hamster Spermatocytes, Cytobios, 1985, vol. 43, pp. 225-232.

    Google Scholar 

  • Allen, J.W.,Collins, B.W, andEvansky, P.A., Spermatid Micronucleus Analyses of Trichloroethylene and Chloral Hydrate Effects in Mice, Mut. Res., 1994, vol. 323, pp. 81-88.

    Google Scholar 

  • Allen, J.W.,Collins, B.W, andSetzer, R.W., Spermatid Micronucleus Analyses of Aging Effects in Hamsters, Mut. Res., 1996, vol. 316, pp. 261-266. Biokhimiya, 1997, vol. 62, no. 12.

    Google Scholar 

  • Bohr, V. andAnson, R.M., DNA Damage, Mutation and Fine Structure DNA Repair in Aging, Mut. Res., 1995, vol. 338, pp. 25-34.

    Google Scholar 

  • Butterfield, A.,Howard, V.,Yatin, S., et al., Free Radical Oxidation of Brain Protein in Accelerated Senescence and Modulation by N-tert-butyl-alpha-phenylnitrone, Proc. Nat. Acad. Sci. USA, 1997, vol. 94, pp. 674-678.

    Google Scholar 

  • Calvo, A.,Martinez, E.,Pastor, L.M., et al., Classification and Quantification of Abnormal Sperm along the Epididymal Tract. Comparison between Adult and Aged Hamsters, Reprod. Nutr. Dev., 1997, vol. 37, pp. 661-673.

    Google Scholar 

  • Crowly, S. andCurtis, H.J., The Development of Somatic Mutations in Mice with Age, Proc. Nat. Acad. Sci. USA, 1963, vol. 49, pp. 626-628.

    Google Scholar 

  • Curtis, H.J., Biological Mechanism Underlying the Aging Process, Science, 1963, vol. 141, pp. 686-694.

    Google Scholar 

  • Curtis, H.J. andMiller, K.I., Chromosome Aberration in Liver Cells of Guinea Pigs, J. Geront., 1971, vol. 26, pp. 292-293.

    Google Scholar 

  • Curtis, H.J.,Leith, J., andTilkley, J., Chromosome Aberration in Liver Cells of Dogs of Different Ages, J. Geront., 1966, vol. 21, pp. 268-270.

    Google Scholar 

  • Fabricant, J.D. andParkening, T.A., Sperm Morphology and Cytogenetic Studies in Ageing C57BI/6 Mice, J. Reprod. Fert., 1982, vol. 66, pp. 485-489.

    Google Scholar 

  • Gosden, R.G.,Richardson, D.W.,Brown, N. andDavidson, D.W., Structure and Gametogenic Potential of Seminiferous Tubules in Ageing Mice, J. Reprod. Fert., 1982, vol. 64, pp. 127-133.

    Google Scholar 

  • Hacker-Klom, U.B., Age Dependence of Murine Spermatogenesis, Z. Naturforsch., 1995, vol. 50, pp. 303-310.

    Google Scholar 

  • He, P. andYasumoto, K., Dietary Butylated Hydroxytoluene Counteracts with Paraquat to Reduce the Rate of Hepatic DNA Single Strand Breaks in Senescence-Accelerated Mice, Mech. Ageing Dev., 1994, vol. 76, pp. 43-48.

    Google Scholar 

  • Higuchi, K., Genetic Characterization of Senescence-Accelerated Mouse (SAM), Exp. Gerontol., 1997, vol. 32, pp. 129-138.

    Google Scholar 

  • Holstein, A.F. andEckmann, S., Multinucleated Spermatocytes and Spermatids in Human Seminiferous Tubules, Andrologia, 1986, vol. 8, pp. 5-16.

    Google Scholar 

  • Hondo, J.C.,Nath, J., andTucker, J.D., Sex Chromosomes, Micronuclei and Aging in Women, Chromosoma, 1994, vol. 103, pp. 186-192.

    Google Scholar 

  • Hosokawa, M.,Abe, T.,Higuchi, K., et al., Management and Design of the Maintenance of SAM Mouse Strains: An Animal Model for Accelerated Senescence and Age-Associated Disorders, Exp. Gerontol., 1997a, vol. 32, pp. 111-116.

    Google Scholar 

  • Hosokawa, M.,Fujisava, H.,Bing-Hua, Z., et al., In vitroStudy of the Mechanisms of Senescence Acceleration, Exp. Gerontol., 1997b, vol. 32, pp. 197-203.

    Google Scholar 

  • Johnson, F.B. andSinclair, D.A., Molecular Biology of Aging, Cell, 1999, vol. 96, pp. 291-302.

    Google Scholar 

  • Johnson, T.E., Genetic Influences on Aging, Exp. Gerontol., 1997, vol. 32, pp. 11-22.

    Google Scholar 

  • Kirkwood, T.B.L and Cremer, T., Cytogerontology since 1881: A Reappraisal of August Weismann and Review of Modern Progress, Hum. Gen., 1982, vol. 60, pp. 101-121.

    Google Scholar 

  • Kohler, S.W.,Provost, S.G.,Fieck, A., et al., Spectra of Spontaneous and Mutagen-Induced Mutation in the lac1Gene in Transgenic Mice, Proc. Nat. Acad. Sci. USA, 1991, vol. 88, pp. 7958-7962.

    Google Scholar 

  • Lee, W. andSohn, H.O., Comparison of Sister Chromatid Exchange in Bone Marrow Cells of SAMP1 and SAMR1 with Age and Effect of Korean Ginseng Extract on Sister Chromatid Exchange, The SAM Model of Senescence, Amsterdam: Excerpta medica, 1994, pp. 129-131.

    Google Scholar 

  • Leonard, A. andJacquet, P., Effect of Age on the Sensitivity of Mouse Spermatogonia to Mutagenic Action, C. R. Seances Soc. Biol. Fil., 1978, vol. 172, pp. 1029-1032.

    Google Scholar 

  • Leonard, A. andLeonard, E.D., Ageing and Chromosome Aberrations in Male Mammalian Germ Cells, Exp. Gerontol., 1975, vol. 10, pp. 309-311.

  • Lowe, X.,Collins, B.,Allen, J., et al., Aneuploidies and Micronuclei in Germ Cells of Male Mice of Advanced Age, Mut. Res., 1995, vol. 338, pp. 59-76.

    Google Scholar 

  • Martus, H.J. andTolle, M.E., Use of Transgenic Mouse Models for Studying Somatic Mutation in Aging, Mut. Res., 1995, vol. 338, pp. 203-213.

    Google Scholar 

  • Miething, A., Multinucleated Spermatocytes in the Aging Human Testes: Formation, Morphology, and Degenerative Fate, Andrologia, 1993, vol. 25, pp. 317-323.

    Google Scholar 

  • Muller, W.U. andStreffer, C., Micronucleus Assays, Advances in Mutagenesis Research, Obe, G., Ed., Berlin: Springer, 1994, pp. 4-134.

    Google Scholar 

  • Nath, J.,Tucker, J.D., andHando, J.C., Y Chromosome Aneuploidy, Micronuclei, Kinetochores and Aging in Men, Chromosoma., 1995, vol. 103, pp. 725-731.

    Google Scholar 

  • Nisitani, S.,Hosokawa, M.,Sasaki, M.S., et al., Acceleration of Chromosome Aberrations in Senescence-Accelerated Strains of Mice, Mut. Res., 1990, vol. 237, pp. 221-228.

    Google Scholar 

  • Odagiri, Y,Uchida, H,Hosokawa, M, et al., Accelerated Accumulation of Somatic Mutations in the Senescence-Accelerated Mouse, Nature Genet., 1998, vol. 19, pp. 116-117.

    Google Scholar 

  • Rapoport, I.A., Mikrogenetika(Microgenetics), Moscow: Nauka, 1965.

    Google Scholar 

  • Rapoport, I.A., ‘Model’ formirovaniya geneticheskogo veshchestva. Khimicheskii mutagenez i sozdanie selektsionnogo materiala ( Model of Genetic Substance Formation. Chemical Mutagenesis and Formation of Selection Material), Moscow: Nauka, 1972, pp. 13-42.

    Google Scholar 

  • Richard, F.,Muleris, M., andDutrillaux, B., The Frequency of Micronuclei with X Chromosome Increases with Age in Human Females, Mut. Res., 1994, vol. 316, pp. 1-7.

    Google Scholar 

  • Rosenbusch, B., Strehler, E., and Sterzik, K., Cytogenetics of Human Spermatozoa: Correlations with Sperm Morphology and Age of Fertile Men, Fertil. Steril, vol. 58, pp. 1071-1072.

  • Rotter, V.,Schwartz, D.,Almon, E., et al., Mice with Reduced Level of Protein Exhibit the Testicular Giant-Cell Degenerative Syndrome, Proc. Nat. Acad. Sci. USA, 1993, vol. 90, pp. 9075-9079.

    Google Scholar 

  • Slagboom, P.E., The Aging Genome: Determinant or Target?, Mut. Res., 1990, vol. 237, pp. 183-187.

    Google Scholar 

  • Stone, J.F. andSandberg, A.A., Sex Chromosome Aneuploidy and Aging, Mut. Res., 1995, vol. 338, pp. 107-113.

    Google Scholar 

  • Szilard, L., On the Nature of the Aging Process, Proc. Nat. Acad. Sci. USA, 1959, vol. 45, pp. 30-45.

    Google Scholar 

  • Takeda, T., Senescence-Accelerated Mouse (SAM): A Biogerontological Resource in Aging Research, Neurobiol. Aging, 1999, vol. 20, pp. 105-110.

    Google Scholar 

  • Takeda, T.,Hosokawa, M.,Takeshita, S., et al., A New Murine Model of Accelerated Senescence, Mech. Aging Dev., 1981, vol. 17, pp. 183-194.

    Google Scholar 

  • Takeda, T.,Hosokawa, M., andHuguchi, K., Senescence-Accelerated Mouse (SAM). A Novel Murine Model of Aging, The SAM Model of Senescence, Takeda, T., Ed., Amsterdam: Excerpta Medica, Elsevier Science B.V., 1994, pp. 15-22.

    Google Scholar 

  • Takeda, T.,Hosokawa, M., andHuguchi, K., Senescence-Accelerated Mouse: A Novel Murine Model of Senescence, Exp. Gerontol., 1997, vol. 32, pp. 105-109.

    Google Scholar 

  • Tobita, M.,Nakamura, S.,Nagano, I., et al., DNA Single-Strand Breaks in Hippocampal Regions of Senescence-Accelerated Mice (SAMP8/Ta) Detected by Modified in situNick Translation Procedure, The SAM Model of Senescence, Takeda, T., Ed., Amsterdam: Excerpta medica, 1994, pp. 125-128.

    Google Scholar 

  • Uryvaeva, I. andDelone, G., An Improved Method of Mouse Liver Micronucleus Analysis: An Application to Age-Related Genetic Alteration and Polyploidy Study, Mut. Res., 1995, vol. 334, pp. 71-80.

    Google Scholar 

  • Uryvaeva, I.V.,Marshak, T.L.,Zakhidov, S.T.,Semenova, M.L., andDelone, G.V., Age-Related Accumulation of Micronuclear Aberrations in Hepatocytes of Mouse Strain SAM with Accelerated Senescence, Dokl. Ross. Akad. Nauk, 1999, vol. 368, pp. 703-705.

    Google Scholar 

  • Walter, C.A.,Intano, G.W.,McCarrey, J.R., et al., Mutation Frequency Declines during Spermatogenesis in Young Mice but Increases in Old Mice, Proc. Nat. Acad. Sci. USA, 1998, vol. 95, pp. 10015-10020.

    Google Scholar 

  • Xia, S.,Higuchi, K.,Shimizu, M., et al., Genetic Typing of the Senescence-Accelerated Mouse (SAM) Strains with Microsatellite Markers, Mam. Genome., 1999, vol. 10, pp. 235-238.

    Google Scholar 

  • Yin, Y.,Stahl, B.C.,DeWolf, W.C., andMorgentaler, A., P53-Mediated Germ Cell Quality Control in Spermatogenesis, Dev. Biol., 1998, vol. 204, pp. 165-171.

  • Zakhidov, S.T., Processes of Normal and Atypical Spermatogenesis in Animals, Doct. Sci. (Biol.) Dissertation, Moscow: Moscow State Univ., 1993.

    Google Scholar 

  • Zakhidov, S.T., Geneticheskaya teoriya stareniya. Sinergetika(Genetic Theory of Aging. Synergetics), Moscow: Moscow State Univ., 1999, pp. 185-193.

    Google Scholar 

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Authors and Affiliations

  1. Biological Faculty, Moscow State University, Vorob'evy gory, Moscow, 119899, Russia

    S. T. Zakhidov

  2. Kol'tsov Institute of Developmental Biology, Russian Academy of Sciences, ul. Vavilova 26, Moscow, 117808, Russia

    O. F. Gordeeva & T. L. Marshak

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  1. S. T. Zakhidov
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  2. O. F. Gordeeva
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  3. T. L. Marshak
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Zakhidov, S.T., Gordeeva, O.F. & Marshak, T.L. A Biological Model of Accelerated Senescence. 1. The Rate of the Spontaneous Mutation Process in Spermatogenesis of Senescence-Accelerated Mice. Biology Bulletin 28, 18–24 (2001). https://doi.org/10.1023/A:1026650519457

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