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Effect of FR167653 on Small Bowel Ischemia-Reperfusion Injury in Dogs

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Abstract

IL-1 and TNF-α are known to be pleiotropiccytokines associated with various inflammatoryconditions such as small intestinal injury afterischemia-reperfusion. FR167653 has been characterized asa potent suppressant of IL-1 and TNF-αproduction. The effect of FR167653 on intestinalreperfusion injury was investigated in a warm ischemiamodel of the canine gut. Sixteen mongrel dogs weredivided into two groups: a control group and a FR groupto which FR167653 was administered. Both the superiormesenteric artery and vein were clamped for 2 hr.Arterial pH, hepatic venous hemoglobin oxygensaturation, intramucosal pH, and the survival rate werewell maintained in the FR group in comparison with thecontrol group after reperfusion. FR167653 inhibited theexpression of IL-1β mRNA. Histologically,ischemia-reperfusion injury was more severe in the control groupthan the FR group. This study suggests that FR167653inhibits proinflammatory cytokines and amelioratesischemia-reperfusion injury of the smallintestine.

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Authors
  1. Izumi Takeyoshi
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  2. Kotaro Iwanami
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  3. Susumu Ohwada
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  4. Yoshiyuki Kawashima
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  5. Kiyoshi Kawata
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  6. Masaaki Aiba
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  7. Junya Kobayashi
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  8. Toru Koyama
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  9. Koshi Matsumoto
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  10. Susumu Satoh
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  11. Yasuo Morishita
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Takeyoshi, I., Iwanami, K., Ohwada, S. et al. Effect of FR167653 on Small Bowel Ischemia-Reperfusion Injury in Dogs. Dig Dis Sci 44, 2334–2343 (1999). https://doi.org/10.1023/A:1026633510390

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