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Microflora of Gastric Biopsies from Patients with Duodenal Ulcer and Gastric Cancer (A Comparative Study of Patients from Korea, Colombia, and the United States)

Digestive Diseases and Sciences volume 43, pages 2291–2295 (1998)Cite this article

Abstract

It remains unclear why the spectrum of H.pylori-related diseases differs among differentgeographic regions. We examined the non-H. pyloricontamination rates of the stomach in patients withduodenal ulcer or gastric adenocarcinoma from threedifferent regions with different spectra of H.pylori-related diseases. Gastric biopsies were culturedfrom patients with duodenal ulcer or histologicallyproven gastric cancer from Seoul, Korea; Bogota,Colombia; and Houston, Texas. The frequency of non-H.pylori contamination was tallied in relation to theclinical diagnosis. Cultures from 247 duodenal ulcer patients and 165 patients with gastric cancerhad bacterial growth. H. pylori was isolated from 207(73.7%) patients with duodenal ulcer and 90 (47.1%)patients with gastric cancer (P < 0.001). In patients with duodenal ulcer (DU) or gastriccancer (GC), the rate of positive cultures for H. pyloriwere not statistically different (P > 0.143 for DU,P > 0.190 for GC) between regions. The frequency of isolation ranged from 69% to 79% for DUpatients and from 39% to 50% for gastric cancerpatients. Non-H. pylori bacterial contamination wasfound more frequently (63%) in Colombian duodenal ulcerpatients compared to 30% ulcer patients from the UnitedStates or Korea (P < 0.001). Non-H. pylori growthoccurred in 50.8-75.5% of cancer patients and wassignificantly lower in US patients than in patients from either Colombia or Korea (P < 0.01).The geographic location as well as disease statusaffects the rate of H. pylori recovery and non-H. pyloricontamination of the stomach and may play a role in the geographic differences in manifestationof H. pylori infection. The fact that the proportion ofgastric cancer patients in the United States with non-H.pylori contamination was significantly less than that of Korea or Colombia shows that thenotion of an almost universal increase in gastricmicrobial content in gastric adenocarcinoma should bereconsidered.

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Authors
  1. Michael S. Osato
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  2. Oscar Gutierrez
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  3. Jong G. Kim
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  4. Gideon Steinbach
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  5. David Y. Graham
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Osato, M.S., Gutierrez, O., Kim, J.G. et al. Microflora of Gastric Biopsies from Patients with Duodenal Ulcer and Gastric Cancer (A Comparative Study of Patients from Korea, Colombia, and the United States). Dig Dis Sci 43, 2291–2295 (1998). https://doi.org/10.1023/A:1026631009190

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  • DOI: https://doi.org/10.1023/A:1026631009190

  • GASTRIC MICROFLORA
  • DUODENAL ULCER
  • GASTRIC CANCER
  • BACTERIAL CONTAMINATION