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Mono- and Bifunctional DNA Glycosylases Involved in Repairing Oxidatively Damaged DNA

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Abstract

DNA repair is a basic biological process providing for the stability and integrity of the genome. Disturbed repair results in premature aging, autoimmune and cardiological disorders, tumorigenesis, etc. Data on enzymes which play key roles in repairing DNA with lesions generated by reactive oxygen species are reviewed. The substrate specificity, mechanism of catalysis, structure of the active center, and specific structural and functional features are described for Escherichia coli mono- and bifunctional DNA glycosylases (endonuclease III, Fpg, MutY, endonuclease VIII, AlkA, MutT) and their prokaryotic and eukaryotic homologs (Ntg1, Ntg2, yOgg1, yOgg2, hOgg1, hOgg2, mOgg1, rOgg1, hMTH, hMYH, MAG, ADPG, and ANPG) which are involved in base excision repair.

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    A. I. Rykhlevskaya & S. A. Kuznetsova

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Rykhlevskaya, A.I., Kuznetsova, S.A. Mono- and Bifunctional DNA Glycosylases Involved in Repairing Oxidatively Damaged DNA. Molecular Biology 34, 860–874 (2000). https://doi.org/10.1023/A:1026627809772

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