As a part of a screening programme developed to evaluate the antimicrobial activity of basidiomycetes, 317 isolates representing 204 species collected in Spain were screened against a range of human clinical pathogens and laboratory controls. Extracts from 45% of the isolates, representing 109 species, showed antimicrobial activity. Antibacterial activity was more pronounced than antifungal activity. The proportion of extracts from basidiomycetes showing antimicrobial activity was similar to or above that obtained for representative orders of Ascomycetes, such as Pezizales and Xylariales, but lower than that produced by members of the orders Diaporthales, Eurotiales, Hypocreales, Leotiales and Sordariales. Suprageneric taxa (orders and families) did not show pronounced differences in their antimicrobial activities though such differences were observed at the genus level, suggesting that the ability to produce these bioactive compounds is not homogenously distributed amongst the basidiomycetes. Isolates from some species showed large differences in their ability to produce metabolites with antimicrobial activity, possibly reflecting genetic differences at the infraspecific level.
This is a preview of subscription content, log in to check access.
Buy single article
Instant access to the full article PDF.
Price includes VAT for USA
Subscribe to journal
Immediate online access to all issues from 2019. Subscription will auto renew annually.
This is the net price. Taxes to be calculated in checkout.
Al-Obeid S, Collatz E & Gutman L (1990) Mechanism of resistance to vancomycin in Enterococcus faecium D.366 and Enterococcus faecalis A.256. Antimicrob. Agents Chemother. 34: 256–266
Anke T (1985) Cytotoxic metabolites from basidiomycetes. In: Ebeshi S (Ed.) Cellular Regulation and Malignant Growth (pp. 169–176). Japan Sci. Soc. Press, Tokyo
Anke T (1989) Basidiomycetes: A source for new bioactive secondary metabolites. Prog. Ind. Microbiol. 27: 51–66
Anke T (1995) The antifungal strobilurins and their possible ecological role. Can. J. Bot. 73(suppl. 1): S940–S945
Benedict RG & Brady LR (1972) Antimicrobial activity of mushroom metabolites. J. Pharm. Sci. 61: 1820–1822
Breheret S, Talou T, Rapior S & Bessiere JM (1997) Monoterpenes in the aromas of fresh wild mushrooms (Basidiomycetes). J. Agric. Food Chem. 45: 831–836
Brizuela MA, García L, Pérez L & Mansur M (1998) Basidiomicetos: nueva fuente de metabolitos secundarios. Rev. Iberoam.Mic. 15: 69–74
Davis AJ & Stone JW (1986) Current problems of chemotherapy of infections with coagulase-negative staphylococci. Eur. J. Clin. Microbiol. 5: 277–281
Dreyfuss MM & Chapela IH (1994) Potential of fungi in the discovery of novel, low-molecular weight pharmaceuticals. In: Gullo VP (Ed.) The Discovery of Natural Products with Therapeutical Potential (pp. 49–80). Butterworth-Heinemann, Stoneham, MA
Florey HW, Chain W, Heatley NG, Jennings MA, Sanders AG, Abraham EP & Florey ME (1949) Antibiotics. Oxford University Press, London
Hautzel R & Anke T (1990) Screening of basidiomycetes and ascomycetes for plant growth regulating substances. Introduction of the gibberellic acid induced de-novo synthesis of hydrolytic enzymes in embryoless seeds of Triticum aestivum as test system. Z. Naturforsch. 45c: 1093–1098
Hawksworth DL, Kirk PM, Sutton BC & Pegler DN (1995) Ainsworth & Bisby's Dictionary of the Fungi (8th Ed.) CAB International: Kew, UK
Heim R (1963) Les Champignons Toxiques et Hallucinogenes, N. Boubee & Cie., París
Janssens L, De Pooter HL, Schamp NM & Vandamme EJ (1992) Production of flavours by microorganisms. Proc. Biochem. 27: 195–215
Kavanagh F, Hervey A & Robbins WJ (1952) Antibiotic substances from basidiomycetes. IX Drosophila subtarata (Batsch ex Fr). Quel. Proc. Natl. Acad. Sci. U.S. 38: 555–560
Korzybski T, Kowszyk-Gindifer Z & Kurylowicz W (1967) Antibiotics. Origin, Nature and Properties. Pergamon Press, Oxford
Kupka J, Anke T, Oberwinkler G, Schramn G & Steglich W (1979) Antibiotics from basidiomycetes. VII. Crinipellis stipitaria (Fr.) Pat. J. Antibiot. 32: 130–135
Löfgren N, Lüning B & Hedström H (1954) The isolation of nebularine and the determination of its structure. Acta Chem. Scand. 8: 670–680
Marumoto R, Klostermeyer D, Steglich W, Wunder A & Anke T (1997) Phlebiachrysoic acids, new inhibitors of leukotriene biosynthesis from Phlebia chrysocrea (Basidiomycete). Leibigs Annalen-Recueil. 2: 313–316
Möller C, Weber G & Dreyfuss MM (1997) Intraspecific diversity in the fungal species Chaunopycnis alba: implications for microbial screening programs. J. Ind. Microbiol. Biotech. 17: 359–372
Peláez F, Collado J, Arenal F, Basilio A, Cabello MA, Díez MT, García JB, González del Val A, González V, Gorrochategui J, Hernández P, Martín I, Platas G & Vicente F (1998) Endophytic fungi from plants living on gypsum soils as a source of secondary metabolites with antimicrobial activity. Mycol. Res. 102: 755–761
Polak A & Hartman PG (1991) Antifungal chemotherapy. Are we winning? Prog. Drug Res. 37: 183–257
Sunderam G, McDonald RJ, Maniatis T, Oleske J, Kapilar R & Reichman LB (1986) Tuberculosis as a manifestation of the acquired inmunodeficiency syndrome (AIDS). J. Am. Med. Assoc. 256: 362–366
Vartivarian SE, Anaissie EJ & Bodey GP (1993) Emerging fungal pathogens in immunocompromisedpatients: classification, diagnosis and management. Clin. Infect. Dis. 17, Supplement. 2: S.487–S.491
Woodward S, Sultan HY, Barrett DK & Pearce RB (1993) Two new antifungal metabolites by Sparassis crispa in culture and in decayed trees. J. Gen. Microbiol. 139: 153–159
Worrall JJ (1991) Media for selective isolation of hymenomycetes. Mycologia 83: 296–302
Zak O (1980) Antibiotics and Pseudomonas aeruginosa. In: Sabath LD (Ed.) Pseudomonas aeruginosa (pp. 133–159). Hans Huber: Berna, CH
About this article
Cite this article
Suay, I., Arenal, F., Asensio, F.J. et al. Screening of basidiomycetes for antimicrobial activities. Antonie Van Leeuwenhoek 78, 129–140 (2000). https://doi.org/10.1023/A:1026552024021
- antibacterial and antifungal activities