Skip to main content

Screening of basidiomycetes for antimicrobial activities

Antonie van Leeuwenhoek volume 78, pages 129–140 (2000)Cite this article

Abstract

As a part of a screening programme developed to evaluate the antimicrobial activity of basidiomycetes, 317 isolates representing 204 species collected in Spain were screened against a range of human clinical pathogens and laboratory controls. Extracts from 45% of the isolates, representing 109 species, showed antimicrobial activity. Antibacterial activity was more pronounced than antifungal activity. The proportion of extracts from basidiomycetes showing antimicrobial activity was similar to or above that obtained for representative orders of Ascomycetes, such as Pezizales and Xylariales, but lower than that produced by members of the orders Diaporthales, Eurotiales, Hypocreales, Leotiales and Sordariales. Suprageneric taxa (orders and families) did not show pronounced differences in their antimicrobial activities though such differences were observed at the genus level, suggesting that the ability to produce these bioactive compounds is not homogenously distributed amongst the basidiomycetes. Isolates from some species showed large differences in their ability to produce metabolites with antimicrobial activity, possibly reflecting genetic differences at the infraspecific level.

This is a preview of subscription content, access via your institution.

Access options

Buy single article

Instant access to the full article PDF.

USD 39.95

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

References

  • Al-Obeid S, Collatz E & Gutman L (1990) Mechanism of resistance to vancomycin in Enterococcus faecium D.366 and Enterococcus faecalis A.256. Antimicrob. Agents Chemother. 34: 256–266

    Google Scholar 

  • Anke T (1985) Cytotoxic metabolites from basidiomycetes. In: Ebeshi S (Ed.) Cellular Regulation and Malignant Growth (pp. 169–176). Japan Sci. Soc. Press, Tokyo

    Google Scholar 

  • Anke T (1989) Basidiomycetes: A source for new bioactive secondary metabolites. Prog. Ind. Microbiol. 27: 51–66

    Google Scholar 

  • Anke T (1995) The antifungal strobilurins and their possible ecological role. Can. J. Bot. 73(suppl. 1): S940–S945

    Google Scholar 

  • Benedict RG & Brady LR (1972) Antimicrobial activity of mushroom metabolites. J. Pharm. Sci. 61: 1820–1822

    PubMed  Google Scholar 

  • Breheret S, Talou T, Rapior S & Bessiere JM (1997) Monoterpenes in the aromas of fresh wild mushrooms (Basidiomycetes). J. Agric. Food Chem. 45: 831–836

    Google Scholar 

  • Brizuela MA, García L, Pérez L & Mansur M (1998) Basidiomicetos: nueva fuente de metabolitos secundarios. Rev. Iberoam.Mic. 15: 69–74

    Google Scholar 

  • Davis AJ & Stone JW (1986) Current problems of chemotherapy of infections with coagulase-negative staphylococci. Eur. J. Clin. Microbiol. 5: 277–281

    PubMed  Google Scholar 

  • Dreyfuss MM & Chapela IH (1994) Potential of fungi in the discovery of novel, low-molecular weight pharmaceuticals. In: Gullo VP (Ed.) The Discovery of Natural Products with Therapeutical Potential (pp. 49–80). Butterworth-Heinemann, Stoneham, MA

    Google Scholar 

  • Florey HW, Chain W, Heatley NG, Jennings MA, Sanders AG, Abraham EP & Florey ME (1949) Antibiotics. Oxford University Press, London

    Google Scholar 

  • Hautzel R & Anke T (1990) Screening of basidiomycetes and ascomycetes for plant growth regulating substances. Introduction of the gibberellic acid induced de-novo synthesis of hydrolytic enzymes in embryoless seeds of Triticum aestivum as test system. Z. Naturforsch. 45c: 1093–1098

    Google Scholar 

  • Hawksworth DL, Kirk PM, Sutton BC & Pegler DN (1995) Ainsworth & Bisby's Dictionary of the Fungi (8th Ed.) CAB International: Kew, UK

    Google Scholar 

  • Heim R (1963) Les Champignons Toxiques et Hallucinogenes, N. Boubee & Cie., París

    Google Scholar 

  • Janssens L, De Pooter HL, Schamp NM & Vandamme EJ (1992) Production of flavours by microorganisms. Proc. Biochem. 27: 195–215

    Google Scholar 

  • Kavanagh F, Hervey A & Robbins WJ (1952) Antibiotic substances from basidiomycetes. IX Drosophila subtarata (Batsch ex Fr). Quel. Proc. Natl. Acad. Sci. U.S. 38: 555–560

    Google Scholar 

  • Korzybski T, Kowszyk-Gindifer Z & Kurylowicz W (1967) Antibiotics. Origin, Nature and Properties. Pergamon Press, Oxford

    Google Scholar 

  • Kupka J, Anke T, Oberwinkler G, Schramn G & Steglich W (1979) Antibiotics from basidiomycetes. VII. Crinipellis stipitaria (Fr.) Pat. J. Antibiot. 32: 130–135

    Google Scholar 

  • Löfgren N, Lüning B & Hedström H (1954) The isolation of nebularine and the determination of its structure. Acta Chem. Scand. 8: 670–680

    Google Scholar 

  • Marumoto R, Klostermeyer D, Steglich W, Wunder A & Anke T (1997) Phlebiachrysoic acids, new inhibitors of leukotriene biosynthesis from Phlebia chrysocrea (Basidiomycete). Leibigs Annalen-Recueil. 2: 313–316

    Google Scholar 

  • Möller C, Weber G & Dreyfuss MM (1997) Intraspecific diversity in the fungal species Chaunopycnis alba: implications for microbial screening programs. J. Ind. Microbiol. Biotech. 17: 359–372

    Google Scholar 

  • Peláez F, Collado J, Arenal F, Basilio A, Cabello MA, Díez MT, García JB, González del Val A, González V, Gorrochategui J, Hernández P, Martín I, Platas G & Vicente F (1998) Endophytic fungi from plants living on gypsum soils as a source of secondary metabolites with antimicrobial activity. Mycol. Res. 102: 755–761

    Google Scholar 

  • Polak A & Hartman PG (1991) Antifungal chemotherapy. Are we winning? Prog. Drug Res. 37: 183–257

    Google Scholar 

  • Sunderam G, McDonald RJ, Maniatis T, Oleske J, Kapilar R & Reichman LB (1986) Tuberculosis as a manifestation of the acquired inmunodeficiency syndrome (AIDS). J. Am. Med. Assoc. 256: 362–366

    Google Scholar 

  • Vartivarian SE, Anaissie EJ & Bodey GP (1993) Emerging fungal pathogens in immunocompromisedpatients: classification, diagnosis and management. Clin. Infect. Dis. 17, Supplement. 2: S.487–S.491

    Google Scholar 

  • Woodward S, Sultan HY, Barrett DK & Pearce RB (1993) Two new antifungal metabolites by Sparassis crispa in culture and in decayed trees. J. Gen. Microbiol. 139: 153–159

    Google Scholar 

  • Worrall JJ (1991) Media for selective isolation of hymenomycetes. Mycologia 83: 296–302

    Google Scholar 

  • Zak O (1980) Antibiotics and Pseudomonas aeruginosa. In: Sabath LD (Ed.) Pseudomonas aeruginosa (pp. 133–159). Hans Huber: Berna, CH

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Centro de Investigación Básica, Merck Sharp & Dohme de España S.A., Josefa Valcárcel 38, E-28027, Madrid, Spain

    Inmaculada Suay, Francisco Arenal, Francisco J. Asensio, Angela Basilio, M. Angeles Cabello, M. Teresa Díez, Juan B. García, Antonio González del Val, Julián Gorrochategui, Pilar Hernández & Fernando Peláez

  2. Centro de Investigación Básica, Merck Sharp & Dohme de España S.A., Josefa Valcárcel 38, E-28027, Madrid, Spain

    M. Francisca Vicente

Authors
  1. Inmaculada Suay
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Francisco Arenal
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Francisco J. Asensio
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Angela Basilio
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. M. Angeles Cabello
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. M. Teresa Díez
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Juan B. García
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Antonio González del Val
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Julián Gorrochategui
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Pilar Hernández
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Fernando Peláez
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. M. Francisca Vicente
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to M. Francisca Vicente.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Suay, I., Arenal, F., Asensio, F.J. et al. Screening of basidiomycetes for antimicrobial activities. Antonie Van Leeuwenhoek 78, 129–140 (2000). https://doi.org/10.1023/A:1026552024021

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1026552024021

  • antibacterial and antifungal activities
  • basidiomycetes